General Information of the Protein
Protein ID
PT02919
Protein Name
P2Y purinoceptor 1
Secondarily
Protein Name
6H1 orphan receptor
ADP receptor
Purinergic receptor
Gene Name
P2RY1
Sequence
MTEALISAALNGTQPELLAGGWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL
    Show/Hide
Organism
Meleagris gallopavo, Wild turkey
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Purine receptor
Function
Receptor for extracellular adenine nucleotides such as ADP (PubMed:8058061). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).
    Show/Hide
Uniprot ID
P49652
Ensembl ID
ENSG00000169860
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000094 , 1321N1
Compound ID Compound Name Compound Formula
CP0077399
((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
   Show/Hide
C11H17N5O10P2S
 2
1
EC50 = 2.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0666532
(Rp)-2-Methylthioadenosine 5'-O-(alpha-Borano)diphosphate
   Show/Hide
C11H17BN5Na3O9P2S
 1
1
EC50 = 33.8 nM
   TI
   LI
   LO
   TS
CP0703725
[[(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanyl-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-(phosphonatomethyl)phosphinate
   Show/Hide
C12H20N5O12P3S
 1
1
EC50 = 80 nM
   TI
   LI
   LO
   TS
CP0043494
ADP
   Show/Hide
C10H15N5O10P2
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0734850
(Rp)-P1-Borano P1,P3-5'-Di-2-methylthioadenosine 5'-Triphosphate tributylammonium
   Show/Hide
C58H113BN13O15P3S2
 1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0775373
(Sp)-P1-Borano P1,P3-5'-Di-2-methylthioadenosine 5'-Triphosphate tributylammonium
   Show/Hide
C58H113BN13O15P3S2
 1
1
EC50 = 190 nM
   TI
   LI
   LO
   TS
CP0674108
(Rp)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-phosphonatooxy-phosphoryl]boranuide
   Show/Hide
C10H15BN5Na3O9P2
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0674107
(Sp)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-phosphonatooxy-phosphoryl]boranuide
   Show/Hide
C10H15BN5Na3O9P2
 1
1
EC50 = 960 nM
   TI
   LI
   LO
   TS
CP0857836
(Sp)-2-Methylthioadenosine 5'-O-(alpha-Borano)diphosphate
   Show/Hide
C11H17BN5Na3O9P2S
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0845423
((((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(oxido(phosphonatomethyl)phosphoryloxy)phosphoryl)trihydroborate
   Show/Hide
C12H21BN5O11P3S
 1
1
EC50 = 17200 nM
   TI
   LI
   LO
   TS