General Information of the Protein
Protein ID
PT02829
Protein Name
Acid-sensing ion channel 3
Secondarily
Protein Name
Amiloride-sensitive cation channel 3
Neuronal amiloride-sensitive cation channel 3
Testis sodium channel 1
Gene Name
ASIC3
Secondarily
Gene Name
ACCN3
SLNAC1
TNAC1
Sequence
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
Acid-sensing ion channel
Function
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
    Show/Hide
Uniprot ID
Primary ID:
Q9UHC3

Secondarily ID:
B2R9V0
O60263
O75906
Q59FN9
Q9UER8
Q9UHC4
    Show/Hide
Ensembl ID
ENSG00000213199
HGNC ID
HGNC:101
Subcellular Location
Cell membrane
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0520893
 Compound Info 
2-(3-(phenylethynyl)phenyl)pyridin-4-amine
   Show/Hide
C19H14N2
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526588
 Compound Info 
6-(6-(2-methylpiperidin-1-yl)pyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C20H25N3
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0504950
 Compound Info 
4-(3-(4-aminopyridin-2-yl)phenyl)but-3-yn-1-ol
   Show/Hide
C15H14N2O
  1
1
IC50 = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0136287
 Compound Info 
6-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C21H24F3N3
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0507681
 Compound Info 
6-(3,5-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C15H13Cl2N
  1
1
IC50 = 3300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0281226
 Compound Info 
6-methyl-N-(4-(6-(piperazin-1-yl)pyridin-3-yl)phenyl)pyridin-2-amine
   Show/Hide
C21H23N5
  1
1
IC50 = 3800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0478544
 Compound Info 
2-phenyl-6-(pyridin-2-ylmethyl)pyridin-4-amine
   Show/Hide
C17H15N3
  1
1
IC50 = 5800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0505033
 Compound Info 
2-phenylpyridin-4-amine
   Show/Hide
C11H10N2
  1
1
IC50 = 6900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0555176
 Compound Info 
6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C16H14F3N
  1
1
IC50 = 7100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0479455
 Compound Info 
N-(6-methylpyridin-2-yl)furo[2,3-c]pyridin-7-amine
   Show/Hide
C13H11N3O
  1
1
IC50 = 9000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526576
 Compound Info 
4-amino-N-(4-chlorophenethyl)-2-propylquinoline-6-carboxamide
   Show/Hide
C21H22ClN3O
  1
1
IC50 = 9600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0422097
 Compound Info 
6-bromo-2-((5-methoxy-1H-indol-3-yl)methyl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C19H19BrN2O
  1
1
IC50 = 10900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0422015
 Compound Info 
6-(4-(4-methylpiperazin-1-yl)phenyl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C20H25N3
  1
1
IC50 = 14400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378234
 Compound Info 
2-methyl-4-(4-(6-methylpyridin-2-ylamino)phenyl)but-3-yn-2-ol
   Show/Hide
C17H18N2O
  1
1
IC50 = 17000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378232
 Compound Info 
6-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C16H17N3
  1
1
IC50 = 19400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0494115
 Compound Info 
4-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-methylquinoline
   Show/Hide
C19H17BrN2
  1
1
IC50 = 27600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0430010
 Compound Info 
1-benzothiophen-2-ylmethanamine
   Show/Hide
C9H9NS
  1
1
IC50 = 97000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0479456
 Compound Info 
6-phenylpyrimidin-4-amine
   Show/Hide
C10H9N3
  1
1
IC50 = 130000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0505032
 Compound Info 
(4-(1H-imidazol-4-yl)phenyl)methanamine
   Show/Hide
C10H11N3
  1
1
IC50 = 160000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496733
 Compound Info 
(3-Methoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C12H13N3O
  1
1
IC50 = 190000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0303199
 Compound Info 
2-ethyl-1H-indene
   Show/Hide
C8H8N2S
  1
1
IC50 = 363000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0520892
 Compound Info 
4-(1H-imidazol-4-yl)aniline
   Show/Hide
C9H9N3
  1
1
IC50 = 430000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0478541
 Compound Info 
6-bromo-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C9H10BrN
  1
1
IC50 = 701000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0478543
 Compound Info 
6-phenylpyridin-2-amine
   Show/Hide
C11H10N2
  1
1
IC50 = 763000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Acid-sensing ion channel 3 (ASIC3) )
Target Type Literature-reported Target