General Information of the Protein
Protein ID
PT02720
Protein Name
Monoacylglycerol lipase ABHD6
Secondarily
Protein Name
2-arachidonoylglycerol hydrolase
Abhydrolase domain-containing protein 6
Gene Name
ABHD6
Sequence
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).
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Uniprot ID
Primary ID:
Q9BV23

Secondarily ID:
B2R7Y9
Q6ZMF7
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Ensembl ID
ENSG00000163686
HGNC ID
HGNC:21398
Subcellular Location
Late endosome membrane
Lysosome membrane
Mitochondrion membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0191477
 Compound Info 
2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid
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C26H27NO6S
  1
1
Ki = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429055
 Compound Info 
2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]amino]acetic acid
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C26H25F3N2O6S
  1
1
Ki = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0400142
 Compound Info 
2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(3-phenoxyphenyl)methyl]amino]acetic acid
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C26H27NO6S
  1
1
Ki = 18300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0329467
 Compound Info 
[(2R)-2-benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanone
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C27H26N4O
  1
1 IC50 = 2.512 nM
CP0476465
 Compound Info 
[(2S)-2-benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanone
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C27H26N4O
  1
1 IC50 = 630.96 nM
CP0191477
 Compound Info 
2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid
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C26H27NO6S
  1
1 Ki = 800 nM
Clinical Information about the Protein
Target 1 ( Monoacylglycerol lipase ABHD6 (ABHD6) )
Target Type Patented-recorded Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06198 Monoacylglycerol lipase ABHD6 Mus musculus, Mouse
 Protein Info