General Information of the Protein
Protein ID
PT02628
Protein Name
Nuclear receptor subfamily 5 group A member 2
Secondarily
Protein Name
Alpha-1-fetoprotein transcription factor
B1-binding factor
CYP7A promoter-binding factor
Hepatocytic transcription factor
Liver receptor homolog 1
Gene Name
NR5A2
Secondarily
Gene Name
B1F
CPF
FTF
Sequence
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 5
>
Nuclear hormone receptor subfamily 5 group A
>
Nuclear hormone receptor subfamily 5 group A member 2
Function
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).
    Show/Hide
Uniprot ID
Primary ID:
O00482

Secondarily ID:
B4E2P3
O95642
Q147U3
    Show/Hide
Ensembl ID
ENSG00000116833
HGNC ID
HGNC:7984
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000017 , HeLa
Compound ID Compound Name Compound Formula
CP0071378
(3S,3aR,6aR)-5-hexyl-6-phenyl-6a-(1-phenylethenyl)-3-(sulfamoylamino)-2,3,3a,4-tetrahydro-1H-pentalene
   Show/Hide
C28H36N2O2S
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0468651
(3R,3aR,6aR)-5-hexyl-6-phenyl-6a-(1-phenylethenyl)-3-(sulfamoylamino)-2,3,3a,4-tetrahydro-1H-pentalene
   Show/Hide
C28H36N2O2S
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0466691
[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl] N-carbamoylsulfamate
   Show/Hide
C29H36N2O4S
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0404734
10-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-4,5,6,6a-tetrahydro-1H-pentalen-2-yl]decanoic acid
   Show/Hide
C32H40O3
 1
1
EC50 = 400 nM
   TI
   LI
   LO
   TS
CP0479019
[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl]urea
   Show/Hide
C29H36N2O
 1
1
EC50 = 500 nM
   TI
   LI
   LO
   TS
CP0436928
[(1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl] sulfamate
   Show/Hide
C28H35NO3S
 1
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
CP0468653
(1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(3-phenylprop-1-en-2-yl)-2,3,6,6a-tetrahydro-1H-pentalen-1-ol
   Show/Hide
C29H36O
 1
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
CP0394008
[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl] sulfamate
   Show/Hide
C28H35NO3S
 1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS
CP0468652
(1R,3aR,6aR)-5-hexyl-3a-[1-(2-methylphenyl)ethenyl]-4-phenyl-2,3,6,6a-tetrahydro-1H-pentalen-1-ol
   Show/Hide
C29H36O
 1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS
CP0466689
1-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl]triazole
   Show/Hide
C30H35N3
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0291441
(1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-ol
   Show/Hide
C28H34O
 2
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
2
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0466690
[(1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl]urea
   Show/Hide
C29H36N2O
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0539147
(1R,3aR,6aR)-5-hexyl-4-(5-hydroxy-2-methylphenyl)-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-ol
   Show/Hide
C29H36O2
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0436933
(1R,3aR,6aR)-3a-[1-(2-fluorophenyl)ethenyl]-5-hexyl-4-phenyl-2,3,6,6a-tetrahydro-1H-pentalen-1-ol
   Show/Hide
C28H33FO
 1
1
EC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0404735
12-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-4,5,6,6a-tetrahydro-1H-pentalen-2-yl]dodecyl 2-(trimethylazaniumyl)ethyl phosphate
   Show/Hide
C39H58NO5P
 1
1
EC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0528980
[(1R,3aS,6aR)-5-hexyl-1-hydroxy-4-phenyl-2,3,6,6a-tetrahydro-1H-pentalen-3a-yl]-phenylmethanone
   Show/Hide
C27H32O2
 1
1
EC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0532504
(1R,3aS,6aR)-3a-benzyl-5-hexyl-4-phenyl-2,3,6,6a-tetrahydro-1H-pentalen-1-ol
   Show/Hide
C27H34O
 1
1
EC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0391481
[(2R)-3-[8-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-4,5,6,6a-tetrahydro-1H-pentalen-2-yl]octanoyloxy]-2-propanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
   Show/Hide
C41H58NO9P
 1
1
EC50 = 13000 nM
   TI
   LI
   LO
   TS
CP0425244
N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-2,3,6,6a-tetrahydro-1H-pentalen-1-yl]acetamide
   Show/Hide
C30H37NO
 1
1
EC50 = 13000 nM
   TI
   LI
   LO
   TS
CP0471108
[(2R)-2,3-di(dodecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
   Show/Hide
C32H64NO8P
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0077809
(3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-amine
   Show/Hide
C28H35N
 1
1 EC50 = 430 nM
Clinical Information about the Protein
Target 1 ( Liver receptor homolog-1 (NR5A2) )
Target Type Literature-reported Target
Target 2 ( Alpha-1-fetoprotein transcription factor (NR5A2) )
Target Type Literature-reported Target