General Information of the Protein
| Protein ID |
PT02628
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| Protein Name |
Nuclear receptor subfamily 5 group A member 2
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| Secondarily Protein Name |
Alpha-1-fetoprotein transcription factor
B1-binding factor
CYP7A promoter-binding factor
Hepatocytic transcription factor
Liver receptor homolog 1
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| Gene Name |
NR5A2
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| Secondarily Gene Name |
B1F
CPF
FTF
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| Sequence |
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 5
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Nuclear hormone receptor subfamily 5 group A
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Nuclear hormone receptor subfamily 5 group A member 2
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| Function |
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Nucleus
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000017 , HeLa
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0077809 |
(3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-amine
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C28H35N
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1 |
| 1 | EC50 = 430 nM | ||
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Clinical Information about the Protein
Target 1 ( Liver receptor homolog-1 (NR5A2) )
| Target Type | Literature-reported Target | ||||
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Target 2 ( Alpha-1-fetoprotein transcription factor (NR5A2) )
| Target Type | Literature-reported Target | ||||
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