General Information of the Protein
| Protein ID |
PT02571
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| Protein Name |
Caspase-9
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| Secondarily Protein Name |
Apoptotic protease Mch-6
Apoptotic protease-activating factor 3
ICE-like apoptotic protease 6
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| Gene Name |
CASP9
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| Secondarily Gene Name |
MCH6
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| Sequence |
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Protease
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Cysteine protease
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Cysteine protease CD clan
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Cysteine protease C14 family
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| Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
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| Uniprot ID |
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| Ensembl ID | |||||
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Clinical Information about the Protein