General Information of the Protein
Protein ID
PT02529
Protein Name
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Secondarily
Protein Name
Cholestenol Delta-isomerase
Delta(8)-Delta(7) sterol isomerase
Emopamil-binding protein
Gene Name
EBP
Sequence
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Isomerase
Function
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
    Show/Hide
Uniprot ID
Primary ID:
Q15125

Secondarily ID:
Q6FGL3
Q6IBI9
    Show/Hide
Ensembl ID
ENSG00000147155
HGNC ID
HGNC:3133
Subcellular Location
Endoplasmic reticulum membrane
Nucleus envelope
Cytoplasmic vesicle
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000018 , HL-60
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0472854
 Compound Info 
(1R,3aR,4R,5S,7aR)-5-[benzyl(methyl)amino]-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C27H45NO
  1
1
IC50 = 7000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530068
 Compound Info 
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-5-[methyl(pent-4-enyl)amino]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C25H47NO
  1
1
IC50 = 7000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0472862
 Compound Info 
(1R,3aR,4R,5S,7aR)-5-(benzylamino)-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C26H43NO
  1
1
IC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0493822
 Compound Info 
(1R,3aR,4R,5S,7aR)-5-amino-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C19H37NO
  1
1
IC50 = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0418875
 Compound Info 
(1R,3aR,4R,5S,7aR)-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-5-(pent-4-enylamino)-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C24H45NO
  1
1
IC50 = 15000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0481542
 Compound Info 
(1R,3aR,4R,5S,7aR)-5-(dimethylamino)-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C21H41NO
  1
1
IC50 = 17000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538319
 Compound Info 
(1R,3aR,4R,5S,7aR)-5-[benzyl(pent-4-enyl)amino]-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C31H51NO
  1
1
IC50 = 17000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410914
 Compound Info 
(1R,3aR,4R,5S,7aR)-5-(dibenzylamino)-3a,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7-hexahydro-1H-inden-4-ol
   Show/Hide
C33H49NO
  1
1
IC50 = 27000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Cholestenol delta-isomerase (EBP) )
Target Type Clinical trial Target