General Information of the Protein
Protein ID
PT02503
Protein Name
Serine/threonine-protein kinase 17B
Secondarily
Protein Name
DAP kinase-related apoptosis-inducing protein kinase 2
Gene Name
STK17B
Secondarily
Gene Name
DRAK2
Sequence
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CAMK protein kinase group
>
CAMK protein kinase DAPK family
Function
Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
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Uniprot ID
O94768
Ensembl ID
ENSG00000081320
HGNC ID
HGNC:11396
Subcellular Location
Nucleus
Cell membrane
Endoplasmic reticulum-Golgi intermediate compartment
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0571832
 Compound Info 
2-[6-(4-ethenylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H12N2O2S2
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0136509
 Compound Info 
2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H10N2O2S3
  1
1
IC50 = 190 nM
 Bioactivity Info 
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CP0331804
 Compound Info 
2-[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O2S3
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0219478
 Compound Info 
2-[6-(3,4-dichlorophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C14H8Cl2N2O2S2
  1
1
IC50 = 310 nM
 Bioactivity Info 
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CP0301785
 Compound Info 
2-[6-[4-(trifluoromethyl)phenyl]thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H9F3N2O2S2
  1
1
IC50 = 340 nM
 Bioactivity Info 
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CP0560083
 Compound Info 
2-[6-(4-ethylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H14N2O2S2
  1
1
IC50 = 380 nM
 Bioactivity Info 
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CP0301784
 Compound Info 
2-[6-[3-(trifluoromethoxy)phenyl]thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H9F3N2O3S2
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0565056
 Compound Info 
2-[6-(3-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O2S3
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0219563
 Compound Info 
2-[6-(4-cyclopropylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C17H14N2O2S2
  1
1
IC50 = 530 nM
 Bioactivity Info 
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CP0562894
 Compound Info 
2-[6-(3-fluoro-4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H11FN2O2S3
  1
1
IC50 = 530 nM
 Bioactivity Info 
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CP0466392
 Compound Info 
2-[6-(4-propan-2-ylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C17H16N2O2S2
  1
1
IC50 = 550 nM
 Bioactivity Info 
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CP0562895
 Compound Info 
2-(6-thiophen-2-ylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
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C12H8N2O2S3
  1
1
IC50 = 650 nM
 Bioactivity Info 
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CP0191504
 Compound Info 
2-[6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C14H9ClN2O2S2
  1
1
IC50 = 680 nM
 Bioactivity Info 
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CP0568728
 Compound Info 
2-[6-(3-fluoro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H11FN2O3S2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0555918
 Compound Info 
2-[6-(4-morpholin-4-ylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C18H17N3O3S2
  1
1
IC50 = 720 nM
 Bioactivity Info 
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CP0565049
 Compound Info 
2-[6-(3,4-difluorophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C14H8F2N2O2S2
  1
1
IC50 = 820 nM
 Bioactivity Info 
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CP0301786
 Compound Info 
2-[6-(4-ethoxycarbonylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C17H14N2O4S2
  1
1
IC50 = 870 nM
 Bioactivity Info 
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CP0353650
 Compound Info 
2-[6-(3-fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C14H9FN2O2S2
  1
1
IC50 = 980 nM
 Bioactivity Info 
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CP0507671
 Compound Info 
2-[6-(2-fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C14H9FN2O2S2
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0136671
 Compound Info 
2-[6-(4-acetylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H12N2O3S2
  1
1
IC50 = 1500 nM
 Bioactivity Info 
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CP0532771
 Compound Info 
2-[6-(2-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O3S2
  1
1
IC50 = 1700 nM
 Bioactivity Info 
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CP0426525
 Compound Info 
2-[6-(3-morpholin-4-ylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C18H17N3O3S2
  1
1
IC50 = 2900 nM
 Bioactivity Info 
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CP0191503
 Compound Info 
2-[6-(4-cyanophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H9N3O2S2
  1
1
IC50 = 3200 nM
 Bioactivity Info 
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CP0031355
 Compound Info 
2-[6-(4-acetamidophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H13N3O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0136672
 Compound Info 
2-[6-(3-acetamidophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H13N3O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0136673
 Compound Info 
2-[6-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0143683
 Compound Info 
2-[6-(4-phenylmethoxyphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C21H16N2O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0203512
 Compound Info 
2-[6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4-yl]oxyacetic acid
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C14H9ClN2O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0219477
 Compound Info 
2-[6-(3-methylsulfanylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O2S3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0426526
 Compound Info 
2-[6-(3,4-dichlorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C14H8Cl2N2O2S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0507672
 Compound Info 
2-[6-(2-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0562896
 Compound Info 
2-[6-(4-methylsulfinylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O3S3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0563432
 Compound Info 
2-[6-(3-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0563433
 Compound Info 
ethyl 2-[[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]acetate
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C17H17N3O2S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0565055
 Compound Info 
2-[6-(4-propan-2-ylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C17H16N2O2S3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0565763
 Compound Info 
2-[6-(4-methylsulfanylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H12N2O2S3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0565889
 Compound Info 
2-[6-(6-acetylpyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C15H11N3O3S2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0568727
 Compound Info 
2-[6-(1-benzothiophen-2-yl)thieno[2,3-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H10N2O2S3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0569299
 Compound Info 
2-[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetamide
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C15H13N3OS3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0571833
 Compound Info 
ethyl 2-[6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4-yl]oxyacetate
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C16H13ClN2O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0579040
 Compound Info 
2-[[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]acetic acid
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C15H13N3O2S2
  1
1
IC50 > 10000 nM
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0136509
 Compound Info 
2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
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C16H10N2O2S3
  2
1 IC50 = 34 nM
2 Kd = 5.6 nM
CP0074947
 Compound Info 
5-(6-bromo-5-methoxy-1H-indol-3-yl)-2-(1H-pyrrol-2-yl)-1,3-oxazole
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C16H12BrN3O2
  1
1 IC50 = 9800 nM
CP0074949
 Compound Info 
5-(6-bromo-4-methoxy-1H-indol-3-yl)-4-iodo-2-(1H-pyrrol-2-yl)-1,3-oxazole
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C16H11BrIN3O2
  1
1 IC50 > 10000 nM
CP0074951
 Compound Info 
5-(6-bromo-4-methoxy-1H-indol-3-yl)-2-(1H-pyrrol-2-yl)-1,3-oxazole
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C16H12BrN3O2
  1
1 IC50 > 10000 nM
CP0088278
 Compound Info 
5-(6-bromo-4-methoxy-1H-indol-3-yl)-2-(5-bromo-1H-pyrrol-2-yl)-1,3-oxazole
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C16H11Br2N3O2
  1
1 IC50 > 10000 nM