General Information of the Protein
Protein ID
PT02461
Protein Name
Neuronal acetylcholine receptor subunit alpha-4
Gene Name
CHRNA4
Secondarily
Gene Name
NACRA4
Sequence
MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
Nicotinic acetylcholine receptor
>
Nicotinic acetylcholine receptor alpha subunit
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
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Uniprot ID
Primary ID:
P43681

Secondarily ID:
Q4JGR7
Q4VAQ5
Q4VAQ6
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Ensembl ID
ENSG00000101204
HGNC ID
HGNC:1958
Subcellular Location
Postsynaptic cell membrane
Cell membrane
Cell membrane
Clinical Information about the Protein
Target 1 ( Neuronal acetylcholine receptor alpha-4 (CHRNA4) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Aneurysm [ICD-11: BD51.Z]
2 Tobacco dependence [ICD-11: 6C4A.2]
3 Alzheimer disease [ICD-11: 8A20]
Approved Drug(s) 1 Approved Drug  1
1 Trimethaphan
 Drug Info 
Approved
Aneurysm
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 CYTISINE
 Drug Info 
Phase 3
Tobacco dependence
Discontinued Drug(s) 1 Discontinued Drug  1
1 ABT-418
 Drug Info 
Discontinued in Phase 2
Alzheimer disease