General Information of the Protein
| Protein ID |
PT02169
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| Protein Name |
Mitogen-activated protein kinase kinase kinase 3
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| Secondarily Protein Name |
MAPK/ERK kinase kinase 3
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| Gene Name |
MAP3K3
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| Secondarily Gene Name |
MAPKKK3
MEKK3
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| Sequence |
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Kinase
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Protein Kinase
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STE protein kinase group
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STE protein kinase STE11 family
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STE protein kinase MEKK2
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| Function |
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
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| Uniprot ID |
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| Ensembl ID | |||||
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Clinical Information about the Protein
Target 1 ( MAPK/ERK kinase kinase 3 (MAP3K3) )
| Target Type | Literature-reported Target | ||||
|---|---|---|---|---|---|
Target 2 ( MEKK3 messenger RNA (MAP3K3 mRNA) )
| Target Type | Literature-reported Target | ||||
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