General Information of the Protein
Protein ID
PT02142
Protein Name
Neurotensin receptor type 1
Secondarily
Protein Name
High-affinity levocabastine-insensitive neurotensin receptor
NTRH
Gene Name
NTSR1
Secondarily
Gene Name
Ntsr
Sequence
MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neurotensin receptor
Function
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity).
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Uniprot ID
P20789
Subcellular Location
Cell membrane
Membrane raft
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0150134
 Compound Info 
(S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid
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C38H64N12O8
  1
1
EC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0064604
 Compound Info 
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
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C78H121N21O20
  2
1
EC50 = 0.04 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 1.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0236745
 Compound Info 
CAS_184162-64-9
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C39H51N5O6
  1
1
Ki = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419100
 Compound Info 
1-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]cyclohexane-1-carboxylic acid
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C28H27ClN4O5
  1
1
Ki = 177 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0411578
 Compound Info 
1-[[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-ylpyrazole-3-carbonyl]amino]cyclohexane-1-carboxylic acid
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C29H29N3O5
  1
1
Ki = 1210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388570
 Compound Info 
1-[[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)pyrazole-3-carbonyl]amino]cyclohexane-1-carboxylic acid
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C25H26FN3O5
  1
1
Ki = 3210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388569
 Compound Info 
1-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbamoyl]cyclohexane-1-carboxylic acid
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C28H27ClN4O5
  1
1
Ki = 7181 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0418649
 Compound Info 
(2S)-2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]methylamino]-2-cyclohexylacetic acid
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C29H31ClN4O4
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386627
 Compound Info 
1-[[5-(2,6-dimethoxyphenyl)-1-naphthalen-1-ylpyrazol-3-yl]carbamoyl]cyclohexane-1-carboxylic acid
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C29H29N3O5
  1
1
Ki = 10162 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398713
 Compound Info 
1-[[1-(4-fluorophenyl)-5-(2-methoxyphenyl)pyrazol-3-yl]carbamoyl]cyclohexane-1-carboxylic acid
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C24H24FN3O4
  1
1
Ki > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0411581
 Compound Info 
1-[[1-(4-fluorophenyl)-5-(2-methoxyphenyl)pyrazole-3-carbonyl]amino]cyclohexane-1-carboxylic acid
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C24H24FN3O4
  1
1
Ki > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432228
 Compound Info 
1-[[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)pyrazol-3-yl]carbamoyl]cyclohexane-1-carboxylic acid
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C25H26FN3O5
  1
1
Ki > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0443418
 Compound Info 
1-[[6-chloro-4-(2,6-dimethoxyphenyl)quinazoline-2-carbonyl]amino]cyclohexane-1-carboxylic acid
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C24H24ClN3O5
  1
1
Ki > 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483755
 Compound Info 
(2S)-2-[[6-chloro-4-(2,6-dimethoxyphenyl)quinazoline-2-carbonyl]amino]-2-cyclohexylacetic acid
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C25H26ClN3O5
  1
1
Ki > 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0487137
 Compound Info 
(2S)-2-[[6-chloro-4-(2,6-dimethoxyphenyl)quinazoline-2-carbonyl]amino]-4-methylpentanoic acid
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C23H24ClN3O5
  1
1
Ki > 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02851 Neurotensin receptor type 1 Mus musculus, Mouse
 Protein Info