General Information of the Protein
Protein ID
PT01965
Protein Name
Adenylate cyclase type 5
Secondarily
Protein Name
ATP pyrophosphate-lyase 5
Adenylate cyclase type V
Adenylyl cyclase 5
Gene Name
ADCY5
Sequence
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Lyase
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
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Uniprot ID
Primary ID:
O95622

Secondarily ID:
B7Z8A6
Q7RTV7
Q8NFM3
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Ensembl ID
ENSG00000173175
HGNC ID
HGNC:236
Subcellular Location
Cell membrane
Cell projection
Cilium
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0392494
 Compound Info 
(1R,3R)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxylic acid hydroxyamide
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C11H14N6O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
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CP0391321
 Compound Info 
(1S,3R)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-N-hydroxy-acetamide
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C12H14N6O2
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0527655
 Compound Info 
(1R,3R)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-hydroxy-acetamide
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C12H16N6O2
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
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CP0504491
 Compound Info 
(1S,3S)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-N-hydroxy-acetamide
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C12H14N6O2
  1
1
IC50 = 2600 nM
 Bioactivity Info 
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CP0535290
 Compound Info 
(1R,3S)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-N-hydroxy-acetamide
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C12H14N6O2
  1
1
IC50 = 4300 nM
 Bioactivity Info 
   TI
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CP0503422
 Compound Info 
(1R,3S)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxylic acid hydroxyamide
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C11H14N6O2
  1
1
IC50 = 4600 nM
 Bioactivity Info 
   TI
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CP0409348
 Compound Info 
(1S,3S)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarboxylic acid hydroxyamide
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C11H12N6O2
  1
1
IC50 = 4900 nM
 Bioactivity Info 
   TI
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CP0363593
 Compound Info 
5-(6-Amino-purin-9-yl)-pentanoic acid hydroxyamide
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C10H14N6O2
  1
1
IC50 = 7600 nM
 Bioactivity Info 
   TI
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CP0358337
 Compound Info 
4-(6-Amino-purin-9-yl)-N-hydroxy-butyramide
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C9H12N6O2
  1
1
IC50 = 7900 nM
 Bioactivity Info 
   TI
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CP0457244
 Compound Info 
(1S,3R)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-acetic acid
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C12H13N5O2
  1
1
IC50 = 8200 nM
 Bioactivity Info 
   TI
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CP0463060
 Compound Info 
(1S,3S)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-hydroxy-acetamide
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C12H16N6O2
  1
1
IC50 = 9400 nM
 Bioactivity Info 
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CP0483624
 Compound Info 
2-[3-(6-Amino-purin-9-yl)-cyclopentyloxy]-N-hydroxy-acetamide
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C12H16N6O3
  1
1
IC50 = 10800 nM
 Bioactivity Info 
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CP0402223
 Compound Info 
2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyloxy]-N-hydroxy-acetamide
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C12H14N6O3
  1
1
IC50 = 13600 nM
 Bioactivity Info 
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CP0508557
 Compound Info 
2-{[2-(6-Amino-purin-9-yl)-ethyl]-methyl-amino}-N-hydroxy-acetamide
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C10H15N7O2
  1
1
IC50 = 15300 nM
 Bioactivity Info 
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CP0565424
 Compound Info 
(1R,3R)-2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-N-hydroxy-acetamide
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C12H14N6O2
  1
1
IC50 = 16300 nM
 Bioactivity Info 
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CP0543927
 Compound Info 
(1R,3S)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-hydroxy-acetamide
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C12H16N6O2
  1
1
IC50 = 25100 nM
 Bioactivity Info 
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CP0536784
 Compound Info 
(1R,3R)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-acetic acid
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C12H15N5O2
  1
1
IC50 = 28800 nM
 Bioactivity Info 
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CP0362765
 Compound Info 
6-(6-Amino-purin-9-yl)-hexanoic acid hydroxyamide
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C11H16N6O2
  1
1
IC50 = 35400 nM
 Bioactivity Info 
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CP0392513
 Compound Info 
(1S,3R)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-hydroxy-acetamide
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C12H16N6O2
  1
1
IC50 = 55000 nM
 Bioactivity Info 
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CP0448689
 Compound Info 
(1S,3R)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxylic acid hydroxyamide
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C11H14N6O2
  1
1
IC50 > 70000 nM
 Bioactivity Info 
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CP0559901
 Compound Info 
(1S,3S)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-acetic acid
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C12H13N5O2
  1
1
IC50 = 73200 nM
 Bioactivity Info 
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CP0507973
 Compound Info 
(1S,3S)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxylic acid hydroxyamide
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C11H14N6O2
  1
1
IC50 = 78000 nM
 Bioactivity Info 
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CP0291612
 Compound Info 
2-[3-(6-Amino-purin-9-yl)-propoxy]-N-hydroxy-acetamide
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C10H14N6O3
  1
1
IC50 = 94000 nM
 Bioactivity Info 
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CP0508897
 Compound Info 
(1R,3R)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarboxylic acid hydroxyamide
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C11H12N6O2
  1
1
IC50 = 100000 nM
 Bioactivity Info 
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CP0538210
 Compound Info 
(1S,3S)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-acetic acid
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C12H15N5O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0363593
 Compound Info 
5-(6-Amino-purin-9-yl)-pentanoic acid hydroxyamide
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C10H14N6O2
  1
1 IC50 = 7600 nM
CP0358337
 Compound Info 
4-(6-Amino-purin-9-yl)-N-hydroxy-butyramide
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C9H12N6O2
  1
1 IC50 = 7900 nM
CP0362765
 Compound Info 
6-(6-Amino-purin-9-yl)-hexanoic acid hydroxyamide
   Show/Hide
C11H16N6O2
  1
1 IC50 = 35400 nM
CP0291612
 Compound Info 
2-[3-(6-Amino-purin-9-yl)-propoxy]-N-hydroxy-acetamide
   Show/Hide
C10H14N6O3
  1
1 IC50 = 94000 nM
Clinical Information about the Protein
Target 1 ( Adenylate cyclase type 5 (AC5) )
Target Type Literature-reported Target