General Information of the Protein
Protein ID
PT01958
Protein Name
Glucose-6-phosphate 1-dehydrogenase
Gene Name
G6PD
Sequence
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
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Uniprot ID
Primary ID:
P11413

Secondarily ID:
D3DWX9
Q16000
Q16765
Q8IU70
Q8IU88
Q8IUA6
Q96PQ2
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Ensembl ID
ENSG00000160211
HGNC ID
HGNC:4057
Subcellular Location
Cytoplasm
Cytosol
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0405881
 Compound Info 
N-[(3S,5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]methanesulfonamide
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C22H37NO3S
  1
1
IC50 = 4800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416350
 Compound Info 
methyl N-[(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]carbamate
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C21H33NO3
  1
1
IC50 = 7800 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0488110
 Compound Info 
(3S,5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-(sulfamoylamino)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
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C21H36N2O3S
  1
1
IC50 = 9200 nM
 Bioactivity Info 
   TI
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CP0416174
 Compound Info 
1-[(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]-3-ethylurea
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C22H36N2O2
  1
1
IC50 = 9500 nM
 Bioactivity Info 
   TI
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CP0125873
 Compound Info 
2-hydroxy-1-[(3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
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C21H34O3
  1
1
IC50 = 12300 nM
 Bioactivity Info 
   TI
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CP0489474
 Compound Info 
(3S,5S,8R,9S,10S,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-(sulfamoylamino)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
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C21H36N2O4S
  1
1
IC50 = 14100 nM
 Bioactivity Info 
   TI
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   TS
CP0416764
 Compound Info 
(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-3-(sulfamoylamino)-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene
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C19H32N2O3S
  1
1
IC50 = 17400 nM
 Bioactivity Info 
   TI
   LI
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CP0038783
 Compound Info 
3beta-hydroxyandrost-5-en-17-one
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C19H28O2
  1
1
IC50 = 24900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0488103
 Compound Info 
N-[(3S,5S,8R,9S,10S,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]methanesulfonamide
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C22H37NO4S
  1
1
IC50 = 35200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0416174
 Compound Info 
1-[(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]-3-ethylurea
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C22H36N2O2
  1
1 IC50 = 1000 nM
CP0416764
 Compound Info 
(3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-3-(sulfamoylamino)-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene
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C19H32N2O3S
  1
1 IC50 = 1200 nM
CP0489474
 Compound Info 
(3S,5S,8R,9S,10S,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-(sulfamoylamino)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
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C21H36N2O4S
  1
1 IC50 = 1200 nM
CP0038783
 Compound Info 
3beta-hydroxyandrost-5-en-17-one
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C19H28O2
  4
1 IC50 = 11300 nM
2 IC50 = 12460 nM
3 Ki = 6200 nM
4 Ki = 8900 nM
Clinical Information about the Protein
Target 1 ( Glucose-6-phosphate dehydrogenase (G6PD) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Chronic obstructive pulmonary disease [ICD-11: CA22]
Approved Drug(s) 1 Approved Drug  1
1 Prasterone
 Drug Info 
Approved
Chronic obstructive pulmonary disease