General Information of the Protein
| Protein ID |
PT01860
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| Protein Name |
Peptidyl-prolyl cis-trans isomerase FKBP1A
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| Secondarily Protein Name |
12 kDa FK506-binding protein
Calstabin-1
FK506-binding protein 1A
Immunophilin FKBP12
Rotamase
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| Gene Name |
FKBP1A
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| Secondarily Gene Name |
FKBP1
FKBP12
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| Sequence |
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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Isomerase
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| Function |
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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| Uniprot ID |
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| Ensembl ID | |||||
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| Subcellular Location |
Cytoplasm
Cytosol
Sarcoplasmic reticulum membrane
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Clinical Information about the Protein