General Information of the Protein
Protein ID
PT01834
Protein Name
Acidic mammalian chitinase
Secondarily
Protein Name
Lung-specific protein TSA1902
Gene Name
CHIA
Sequence
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
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Uniprot ID
Primary ID:
Q9BZP6

Secondarily ID:
Q32W79
Q32W80
Q3B866
Q5U5Z5
Q5VUV4
Q86UD8
Q9ULY3
Q9ULY4
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Ensembl ID
ENSG00000134216
HGNC ID
HGNC:17432
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0773613
 Compound Info 
(S)-3-(4-(7-chloro-3-(4-chlorobenzyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C24H29Cl2N7
  1
1
IC50 = 0.7 nM
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CP0836935
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C24H30ClN7
  1
1
IC50 = 1.4 nM
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CP0839360
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-isobutylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C22H33ClN6O
  1
1
IC50 = 1.6 nM
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CP0112463
 Compound Info 
3-[[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]methyl]phenol
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C22H27ClN6O
  1
1
IC50 = 2 nM
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CP0258496
 Compound Info 
2-[[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]methyl]phenol
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C22H27ClN6O
  1
1
IC50 = 2 nM
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CP0368213
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2-chlorophenyl)methyl]piperidin-4-amine
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C22H26Cl2N6
  2
1
IC50 = 3 nM
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2
IC50 = 3.5 nM
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CP0456481
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(naphthalen-1-ylmethyl)piperidin-4-amine
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C26H29ClN6
  1
1
IC50 = 3.4 nM
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CP0719096
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-isopropylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C21H31ClN6O
  1
1
IC50 = 3.4 nM
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CP0163081
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(4-chlorophenyl)methyl]piperidin-4-amine
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C22H26Cl2N6
  1
1
IC50 = 4 nM
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CP0352721
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[(2-chloro-4-fluorophenyl)methyl]-N-[2-(4-chlorophenyl)ethyl]piperidin-4-amine
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C22H25Cl2FN6
  1
1
IC50 = 5 nM
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CP0409606
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-benzyl-N-[2-(4-chlorophenyl)ethyl]piperidin-4-amine
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C22H27ClN6
  2
1
IC50 = 5 nM
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2
IC50 = 5.4 nM
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CP0511392
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2,5-difluorophenyl)methyl]piperidin-4-amine
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C22H25ClF2N6
  1
1
IC50 = 5 nM
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CP0258485
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(3-chlorophenyl)methyl]piperidin-4-amine
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C22H26Cl2N6
  1
1
IC50 = 6 nM
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CP0957936
 Compound Info 
((2R,5S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)morpholin-2-yl)methanol
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C19H27ClN6O2
  1
1
IC50 = 6.8 nM
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CP0686385
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C23H27ClN6O
  1
1
IC50 = 7 nM
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CP0801699
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-7-fluoro-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C23H26ClFN6O
  1
1
IC50 = 7 nM
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CP0719097
 Compound Info 
2-((2R,5S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)morpholin-2-yl)propan-2-ol
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C21H31ClN6O2
  1
1
IC50 = 7 nM
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CP0912043
 Compound Info 
(S)-3-(4-(7-chloro-3-(4-chlorobenzyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C23H26Cl2N6O
  1
1
IC50 = 8 nM
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CP0437217
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(cyclohexylmethyl)piperidin-4-amine
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C22H33ClN6
  1
1
IC50 = 8.7 nM
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CP0447368
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-bromophenyl)ethyl]-N-(2-methylpropyl)piperidin-4-amine
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C19H29BrN6
  1
1
IC50 = 8.7 nM
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CP0946531
 Compound Info 
5-(4-((2R,5S)-5-(4-Chlorobenzyl)-2-(methoxymethyl)-morpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C20H29ClN6O2
  1
1
IC50 = 8.9 nM
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CP0719098
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C19H27ClN6O
  2
1
IC50 = 9 nM
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2
Ki = 4.8 nM
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CP0112464
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[[3-(trifluoromethyl)phenyl]methyl]piperidin-4-amine
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C23H26ClF3N6
  1
1
IC50 = 12 nM
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CP0912045
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-6-methylene-1,4-oxazepan-4-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C20H27ClN6O
  1
1
IC50 = 12 nM
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CP0323379
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methylpropyl)piperidin-4-amine
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C19H29ClN6
  3
1
IC50 = 14.2 nM
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2
IC50 = 15 nM
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3
Ki = 13.5 nM
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CP0487578
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(3-chloropyridin-4-yl)methyl]piperidin-4-amine
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C21H25Cl2N7
  1
1
IC50 = 15 nM
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CP0220465
 Compound Info 
3-[4-[(2S,4S)-2-[(4-chlorophenyl)methyl]-4-methoxypyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H27ClN6O
  1
1
IC50 = 19 nM
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CP0390143
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(oxolan-2-ylmethyl)piperidin-4-amine
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C20H29ClN6O
  1
1
IC50 = 21 nM
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CP0230989
 Compound Info 
3-[4-[(3S)-3-[(4-chlorophenyl)methyl]morpholin-4-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6O
  1
1
IC50 = 22 nM
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CP0175801
 Compound Info 
3-[4-[(2R)-2-[(4-chlorophenyl)methyl]piperidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H27ClN6
  1
1
IC50 = 23 nM
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CP0956391
 Compound Info 
(2R,5S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)-N-methylmorpholine-2-carboxamide
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C20H28ClN7O2
  1
1
IC50 = 24 nM
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CP0220464
 Compound Info 
3-[4-[(2S,4R)-2-[(4-chlorophenyl)methyl]-4-methoxypyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H27ClN6O
  1
1
IC50 = 26 nM
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CP0161810
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]-N-methylethanesulfonamide
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C18H28ClN7O2S
  1
1
IC50 = 28 nM
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CP0363328
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methoxy-2-methylpropyl)piperidin-4-amine
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C20H31ClN6O
  1
1
IC50 = 28 nM
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CP0773610
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C22H26ClN7O
  1
1
IC50 = 30 nM
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CP0157956
 Compound Info 
N-[2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethyl]methanesulfonamide
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C18H28ClN7O2S
  1
1
IC50 = 37 nM
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CP0220467
 Compound Info 
(3S,5S)-1-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-5-[(4-chlorophenyl)methyl]pyrrolidin-3-ol
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C18H25ClN6O
  1
1
IC50 = 39 nM
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CP0075800
 Compound Info 
1-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]-2-methylpropan-2-ol
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C19H29ClN6O
  1
1
IC50 = 40 nM
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CP0808278
 Compound Info 
(S)-4-(1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl)-3-(4-chlorobenzyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-7-carbonitrile
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C24H26ClN7O
  1
1
IC50 = 49 nM
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CP0075840
 Compound Info 
(3R,5S)-1-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-5-[(4-chlorophenyl)methyl]pyrrolidin-3-ol
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C18H25ClN6O
  1
1
IC50 = 50 nM
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CP0946120
 Compound Info 
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-ethylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C20H29ClN6O
  1
1
IC50 = 54 nM
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CP0773609
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-2,3-dihydropyrido[4,3-f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C22H26ClN7O
  1
1
IC50 = 55 nM
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CP0157955
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(oxan-2-ylmethyl)piperidin-4-amine
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C21H31ClN6O
  1
1
IC50 = 68 nM
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CP0773607
 Compound Info 
(S)-3-(4-(7,9-dichloro-3-(4-chlorobenzyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C23H25Cl3N6O
  1
1
IC50 = 68 nM
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CP0458641
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-bromophenyl)ethyl]-N-ethylpiperidin-4-amine
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C17H25BrN6
  1
1
IC50 = 73 nM
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CP0369392
 Compound Info 
3-[4-[(2R)-2-[(4-chlorophenyl)methyl]pyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6
  1
1
IC50 = 73 nM
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CP0220471
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(oxetan-3-yl)piperidin-4-amine
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C18H25ClN6O
  1
1
IC50 = 83 nM
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CP0370214
 Compound Info 
3-[4-[(2S,5S)-2-[(4-chlorophenyl)methyl]-5-methyl-4-(2-methylpropyl)piperazin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C23H36ClN7
  1
1
IC50 = 84 nM
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CP0352216
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-(2-methoxyethyl)piperidin-4-amine
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C18H27ClN6O
  1
1
IC50 = 98 nM
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CP0262465
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2S)-2-methoxypropyl]piperidin-4-amine
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C19H29ClN6O
  1
1
IC50 = 103 nM
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CP0238581
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethanol
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C17H25ClN6O
  1
1
IC50 = 111 nM
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CP0452090
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-propan-2-ylpiperidin-4-amine
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C18H27ClN6
  1
1
IC50 = 134 nM
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CP0238580
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-[(2R)-2-methoxypropyl]piperidin-4-amine
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C19H29ClN6O
  1
1
IC50 = 135 nM
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CP0434613
 Compound Info 
(2S)-1-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]propan-2-ol
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C18H27ClN6O
  1
1
IC50 = 135 nM
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CP0262463
 Compound Info 
N-[2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethyl]acetamide
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C19H28ClN7O
  1
1
IC50 = 163 nM
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CP0417516
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-ethylpiperidin-4-amine
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C17H25ClN6
  1
1
IC50 = 182 nM
 Bioactivity Info 
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CP0109502
 Compound Info 
(2R)-1-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]propan-2-ol
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C18H27ClN6O
  1
1
IC50 = 185 nM
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CP0773612
 Compound Info 
(S)-2-((1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl)(benzyl)amino)-3-(4-chlorophenyl)propan-1-ol
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C23H29ClN6O
  1
1
IC50 = 245 nM
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CP0686386
 Compound Info 
(S)-3-(4-(3-(4-chlorobenzyl)-2,3-dihydropyrido[3,4-f][1,4]oxazepin-4(5H)-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine
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C22H26ClN7O
  1
1
IC50 = 290 nM
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CP0476153
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-bromophenyl)ethyl]-N-methylpiperidin-4-amine
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C16H23BrN6
  1
1
IC50 = 348 nM
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CP0365402
 Compound Info 
3-[4-[(2S,3S)-2-[(4-chlorophenyl)methyl]-3-methoxyazetidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6O
  1
1
IC50 = 395 nM
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CP0311092
 Compound Info 
3-[4-[(2S)-2-[(4-chlorophenyl)methyl]-4-methylpiperazin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C19H28ClN7
  1
1
IC50 = 400 nM
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CP0220469
 Compound Info 
1-[2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]ethyl]-3-methylurea
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C19H29ClN8O
  1
1
IC50 = 425 nM
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CP0964740
 Compound Info 
(S)-1-(5-amino-1H-1,2,4-triazol-3-yl)-N-(1-(4-chlorophenoxy)-3-(4-chlorophenyl)propan-2-yl)-N-methylpiperidin-4-amine
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C23H28Cl2N6O
  1
1
IC50 = 580 nM
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CP0417514
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-chlorophenyl)ethyl]-N-methylpiperidin-4-amine
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C16H23ClN6
  1
1
IC50 = 660 nM
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CP0352217
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]-N-methylacetamide
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C18H26ClN7O
  1
1
IC50 = 690 nM
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CP0719095
 Compound Info 
5-(4-((2R,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)-piperidin-1-yl)-4H-1,2,4-triazol-3-amine
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C19H27ClN6O
  1
1
IC50 = 830 nM
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CP0955868
 Compound Info 
(S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-3-(4-chlorobenzyl)thiomorpholine-1,1-Dioxide
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C18H25ClN6O2S
  1
1
IC50 = 850 nM
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CP0437222
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-ethylphenyl)ethyl]-N-methylpiperidin-4-amine
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C18H28N6
  1
1
IC50 = 970 nM
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CP0220472
 Compound Info 
2-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-[2-(4-chlorophenyl)ethyl]amino]acetic acid
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C17H23ClN6O2
  1
1
IC50 = 1040 nM
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CP0417517
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-methyl-N-[2-(4-methylphenyl)ethyl]piperidin-4-amine
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C17H26N6
  1
1
IC50 = 1111 nM
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CP0957172
 Compound Info 
(S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)piperazin-2-one
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C18H24ClN7O
  1
1
IC50 = 1300 nM
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CP0220468
 Compound Info 
3-[4-[3-(4-chlorophenyl)piperidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C18H25ClN6
  1
1
IC50 = 1350 nM
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CP0437223
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-cyclopropylphenyl)ethyl]-N-methylpiperidin-4-amine
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C19H28N6
  1
1
IC50 = 1545 nM
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CP0447331
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(2,4-dichlorophenyl)ethyl]-N-methylpiperidin-4-amine
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C16H22Cl2N6
  1
1
IC50 = 2025 nM
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CP0447329
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-methyl-N-[2-(4-propan-2-ylphenyl)ethyl]piperidin-4-amine
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C19H30N6
  1
1
IC50 = 4137 nM
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CP0041008
 Compound Info 
3-[4-[2-(4-bromophenoxy)ethyl]piperazin-1-yl]-1H-1,2,4-triazol-5-amine
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C14H19BrN6O
  1
1
IC50 = 5450 nM
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CP0157970
 Compound Info 
3-[4-[3-(4-chlorophenyl)pyrrolidin-1-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C17H23ClN6
  1
1
IC50 = 5950 nM
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CP0882792
 Compound Info 
(S)-4-(1-(5-Amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-3-(4-chlorobenzyl)piperazin-2-one
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C18H24ClN7O
  1
1
IC50 = 6400 nM
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CP0478236
 Compound Info 
1-[4-(5-amino-1H-1,2,4-triazol-3-yl)piperazin-1-yl]-2-(4-bromophenoxy)ethanone
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C14H17BrN6O2
  1
1
IC50 = 12250 nM
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CP0437221
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[2-(4-tert-butylphenyl)ethyl]-N-methylpiperidin-4-amine
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C20H32N6
  1
1
IC50 = 13200 nM
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CP0478235
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-methyl-N-(2-phenylethyl)piperidin-4-amine
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C16H24N6
  1
1
IC50 = 18450 nM
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CP0417510
 Compound Info 
N-[[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]methyl]-4-bromobenzamide
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C15H19BrN6O
  1
1
IC50 > 100000 nM
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CP0417513
 Compound Info 
N-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-1-(4-bromophenyl)-N-methylmethanesulfonamide
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C15H21BrN6O2S
  1
1
IC50 > 100000 nM
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CP0437218
 Compound Info 
1-(5-amino-1H-1,2,4-triazol-3-yl)-N-[(4-bromophenyl)methyl]piperidine-4-carboxamide
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C15H19BrN6O
  1
1
IC50 > 100000 nM
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CP0437220
 Compound Info 
1-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-3-(4-bromophenyl)urea
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C14H18BrN7O
  1
1
IC50 > 100000 nM
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CP0447367
 Compound Info 
N-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-2-(4-bromophenyl)acetamide
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C15H19BrN6O
  1
1
IC50 > 100000 nM
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CP0458642
 Compound Info 
3-[4-[[(4-bromophenyl)methyl-methylamino]methyl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
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C16H23BrN6
  1
1
IC50 > 100000 nM
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CP0458649
 Compound Info 
N-[1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl]-1-(4-bromophenyl)methanesulfonamide
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C14H19BrN6O2S
  1
1
IC50 > 3325 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0041008
 Compound Info 
3-[4-[2-(4-bromophenoxy)ethyl]piperazin-1-yl]-1H-1,2,4-triazol-5-amine
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C14H19BrN6O
  2
1 IC50 = 210 nM
2 Kd = 1690 nM
Clinical Information about the Protein
Target 1 ( Acidic mammalian chitinase (CHIA) )
Target Type Literature-reported Target