General Information of the Protein
Protein ID
PT01706
Protein Name
Receptor-type tyrosine-protein phosphatase C
Secondarily
Protein Name
Leukocyte common antigen
T200
Gene Name
PTPRC
Secondarily
Gene Name
CD45
Sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphatase
>
Protein Phosphatase
>
Tyrosine protein phosphatase
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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Uniprot ID
Primary ID:
P08575

Secondarily ID:
A0A0A0MT22
A8K7W6
Q16614
Q9H0Y6
X6R433
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Ensembl ID
ENSG00000081237
HGNC ID
HGNC:9666
Subcellular Location
Cell membrane
Membrane raft
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000001 , Jurkat
Compound ID Compound Name Compound Formula
CP0858217
[(2-Cyclohexylsulfanyl-5-nitro-phenyl)-hydroxy-methyl]-phosphonic acid
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C13H18NO6PS
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0847497
[(2-Azido-5-nitro-phenyl)-hydroxy-methyl]-phosphonic acid
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C7H7N4O6P
 1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0862980
[Hydroxy-(3-nitro-phenyl)-methyl]-phosphonic acid
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C7H8NO6P
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0860313
[(2-Chloro-5-nitro-phenyl)-hydroxy-methyl]-phosphonic acid
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C7H7ClNO6P
 1
1
IC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0847413
[Hydroxy-(4-nitro-phenyl)-methyl]-phosphonic acid
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C7H8NO6P
 1
1
IC50 = 28000 nM
   TI
   LI
   LO
   TS
CP0448451
[hydroxy-(5-nitrothiophen-3-yl)methyl]phosphonic acid
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C5H6NO6PS
 1
1
IC50 = 38000 nM
   TI
   LI
   LO
   TS
CP0448853
[1-hydroxy-1-(3-nitrophenyl)ethyl]phosphonic acid
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C8H10NO6P
 1
1
IC50 = 58000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Leukocyte common antigen (PTPRC) )
Target Type Clinical trial Target