General Information of the Protein
| Protein ID |
PT01433
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| Protein Name |
Chymase
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| Secondarily Protein Name |
Alpha-chymase
Mast cell protease I
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| Gene Name |
CMA1
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| Secondarily Gene Name |
CYH
CYM
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| Sequence |
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
>
Protease
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Serine protease
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Serine protease PA clan
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Serine protease S1A subfamily
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| Function |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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| Uniprot ID |
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| Ensembl ID | |||||
| HGNC ID | |||||
| Subcellular Location |
Secreted
Cytoplasmic granule
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Clinical Information about the Protein
Target 1 ( Chymase (CYM) )
| Target Type | Clinical trial Target | ||||
|---|---|---|---|---|---|
| Disease | 4 Target-related Diseases | 4 | |||
| 1 | Myocardial infarction [ICD-11: BA41-BA43] | ||||
| 2 | Chronic obstructive pulmonary disease [ICD-11: CA22] | ||||
| 3 | Gram-positive bacterial infection [ICD-11: 1B74-1G40] | ||||
| 4 | Cardiovascular disease [ICD-11: BA00-BE2Z] | ||||
| Clinical Trial Drug(s) | 3 Clinical Trial Drugs | 3 | |||
| 1 | BAY 1142524 | Phase 2 | |||
| 2 | JNJ-10311795 | Phase 2 | |||
| 3 | SUN13834 | Phase 2 | |||
| Investigative Drug(s) | 1 Investigative Drug | 1 | |||
| 1 | KM-01221 | Investigative | |||