General Information of the Protein
Protein ID
PT01412
Protein Name
BMP-2-inducible protein kinase
Gene Name
BMP2K
Secondarily
Gene Name
BIKE
HRIHFB2017
Sequence
MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSAQLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFDEITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLSWHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQSQQSQPVELDPFGAAPFPSKQ
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Other protein kinase group
>
Other protein kinase NAK family
Function
May be involved in osteoblast differentiation.
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Uniprot ID
Primary ID:
Q9NSY1

Secondarily ID:
O94791
Q4W5H2
Q8IYF2
Q8N2G7
Q8NHG9
Q9NTG8
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Ensembl ID
ENSG00000138756
HGNC ID
HGNC:18041
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0519352
 Compound Info 
N-[6-[3-(cyclobutylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H22N4O3S
  1
1
IC50 = 707 nM
 Bioactivity Info 
   TI
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CP0275668
 Compound Info 
4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H25BrN6O3S
  1
1
IC50 = 1020 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0423041
 Compound Info 
N-[6-[3-[(3-fluorophenyl)methylsulfonylamino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C24H21FN4O3S
  1
1
IC50 = 1190 nM
 Bioactivity Info 
   TI
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   TS
CP0423046
 Compound Info 
N-[6-[3-(cyclopropylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H20N4O3S
  1
1
IC50 = 1420 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0555200
 Compound Info 
N-[6-[3-(2-methylpropylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H24N4O3S
  1
1
IC50 = 1490 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0474150
 Compound Info 
N-[6-[3-[(2-fluorophenyl)methylsulfonylamino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C24H21FN4O3S
  1
1
IC50 = 1620 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519634
 Compound Info 
N-[6-[3-[(2,2,2-trifluoroethylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H19F3N4O3S
  1
1
IC50 = 1620 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489853
 Compound Info 
N-[6-[3-[(3,3,3-trifluoropropylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H21F3N4O3S
  1
1
IC50 = 1890 nM
 Bioactivity Info 
   TI
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CP0542395
 Compound Info 
N-[6-[3-[[ethyl(methyl)sulfamoyl]amino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H23N5O3S
  1
1
IC50 = 1890 nM
 Bioactivity Info 
   TI
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CP0489852
 Compound Info 
N-[6-[3-(propylsulfonylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C20H22N4O3S
  1
1
IC50 = 2180 nM
 Bioactivity Info 
   TI
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CP0423045
 Compound Info 
N-[6-[3-[(cyclopropylmethylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C22H24N4O3S
  1
1
IC50 = 2740 nM
 Bioactivity Info 
   TI
   LI
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CP0469511
 Compound Info 
N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H25N5O3S
  1
1
IC50 = 2800 nM
 Bioactivity Info 
   TI
   LI
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CP0423044
 Compound Info 
N-[6-[3-[(4-fluorophenyl)methylsulfonylamino]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C24H21FN4O3S
  1
1
IC50 = 2950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474151
 Compound Info 
N-[6-[3-[[[ethyl(methyl)sulfamoyl]amino]methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H25N5O3S
  1
1
IC50 = 2960 nM
 Bioactivity Info 
   TI
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CP0275673
 Compound Info 
N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C22H24BrN7O3S
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
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CP0423042
 Compound Info 
N-[6-[3-[[[methyl(2,2,2-trifluoroethyl)sulfamoyl]amino]methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H22F3N5O3S
  1
1
IC50 = 3030 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0555201
 Compound Info 
N-[6-[3-[(diethylsulfamoylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C22H27N5O3S
  1
1
IC50 = 3830 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0423043
 Compound Info 
N-[6-[3-[(2-methylpropylsulfonylamino)methyl]phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C22H26N4O3S
  1
1
IC50 = 6550 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0275668
 Compound Info 
4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H25BrN6O3S
  1
1 IC50 = 38 nM
CP0275673
 Compound Info 
N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C22H24BrN7O3S
  1
1 IC50 = 40 nM
CP0469511
 Compound Info 
N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
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C21H25N5O3S
  1
1 Ki = 17 nM
Clinical Information about the Protein
Target 1 ( BMP-2-inducible protein kinase (BMP2K) )
Target Type Literature-reported Target