General Information of the Protein
Protein ID
PT01339
Protein Name
Alpha-1A adrenergic receptor
Secondarily
Protein Name
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Gene Name
ADRA1A
Secondarily
Gene Name
Adra1c
Sequence
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Adrenergic receptor
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
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Uniprot ID
P43140
Ensembl ID
ENSG00000120907
Subcellular Location
Nucleus membrane
Cell membrane
Cytoplasm
Membrane
Caveola
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000880 , COS
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0049709
 Compound Info 
2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quinazolin-4-ylamine
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C18H21N5O3
  1
1
Ki = 0.72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0110274
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3,3-diphenyl-propan-1-one
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C29H31N5O3
  1
1
Ki = 1.48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0096797
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-4-phenyl-butane-1,4-dione
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C24H27N5O4
  1
1
Ki = 5.68 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0049357
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-isopropyl-6-methoxy-phenoxy)-ethanone
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C26H33N5O5
  1
1
Ki = 7.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0122632
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-phenyl-propane-1,3-dione
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C23H25N5O4
  1
1
Ki = 10.99 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0122703
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-methoxy-phenoxy)-ethanone
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C23H27N5O5
  1
1
Ki = 18.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0358354
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2,6-dimethoxy-phenoxy)-ethanone
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C24H29N5O6
  1
1
Ki = 36.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0270867
 Compound Info 
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-isopropyl-6-methoxy-phenoxy)-propan-1-one
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C27H35N5O5
  1
1
Ki = 155.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01089 Alpha-1A adrenergic receptor Homo sapiens, Human
 Protein Info 
PT02060 Alpha-1A adrenergic receptor Bos taurus, Bovine
 Protein Info