General Information of the Protein
| Protein ID |
PT01301
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| Protein Name |
Bcl2-associated agonist of cell death
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| Secondarily Protein Name |
Bcl-2-binding component 6
Bcl-2-like protein 8
Bcl-xL/Bcl-2-associated death promoter
Bcl2 antagonist of cell death
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| Gene Name |
BAD
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| Secondarily Gene Name |
BBC6
BCL2L8
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| Sequence |
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Other cytosolic protein
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| Function |
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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| Uniprot ID |
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| Subcellular Location |
Mitochondrion outer membrane
Cytoplasm
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000091 , MV4-11
