General Information of the Protein
Protein ID
PT01212
Protein Name
Serine/threonine-protein kinase 17A
Secondarily
Protein Name
DAP kinase-related apoptosis-inducing protein kinase 1
Gene Name
STK17A
Secondarily
Gene Name
DRAK1
Sequence
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CAMK protein kinase group
>
CAMK protein kinase DAPK family
Function
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
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Uniprot ID
Primary ID:
Q9UEE5

Secondarily ID:
A4D1V6
Q8IVC8
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Ensembl ID
ENSG00000164543
HGNC ID
HGNC:11395
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0496360
 Compound Info 
N-[3-[[5-bromo-4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C23H30BrN7O2
  1
1
IC50 = 4.47 nM
 Bioactivity Info 
   TI
   LI
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CP0201442
 Compound Info 
N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C26H36N6O2
  1
1
IC50 = 43.2 nM
 Bioactivity Info 
   TI
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   LO
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CP0275666
 Compound Info 
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]-5-cyclopropylpyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C26H35N7O2
  1
1
IC50 = 58.2 nM
 Bioactivity Info 
   TI
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CP0496361
 Compound Info 
N-[3-[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C18H23BrF3N7O
  1
1
IC50 = 126 nM
 Bioactivity Info 
   TI
   LI
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CP0275665
 Compound Info 
5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
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C20H24BrN7O
  1
1
IC50 = 638 nM
 Bioactivity Info 
   TI
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CP0567307
 Compound Info 
N-[3-[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C21H28F3N7O
  1
1
IC50 = 874 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0275672
 Compound Info 
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C23H31N7O2
  1
1
IC50 = 2311 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0275671
 Compound Info 
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
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C23H29N7O
  1
1
IC50 = 3622 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0169053
 Compound Info 
4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C17H17BrF3N7O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0260709
 Compound Info 
4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
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C15H17F3N8
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0273555
 Compound Info 
4-[[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C25H30N6O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0275668
 Compound Info 
4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H25BrN6O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0275670
 Compound Info 
4-[[[2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H26N6O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0275673
 Compound Info 
N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C22H24BrN7O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0275674
 Compound Info 
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
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C18H21F3N8
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0344151
 Compound Info 
4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
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C20H25N7O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496362
 Compound Info 
5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
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C15H16BrF3N8
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0496364
 Compound Info 
4-[[[2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C17H18F3N7O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0543933
 Compound Info 
N-[3-[[5-cyclopropyl-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C25H29N7O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0551443
 Compound Info 
4-[[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C20H22F3N7O2S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0551444
 Compound Info 
N-[3-[[4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C22H25N7O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0571203
 Compound Info 
N-[3-[[2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C18H24F3N7O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0004106
 Compound Info 
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one
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C28H26N4O3
  4
1 IC50 = 30.4 nM
2 IC50 = 31.4 nM
3 Kd = 14 nM
4 Kd = 23 nM
CP0567307
 Compound Info 
N-[3-[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C21H28F3N7O
  1
1 IC50 = 202 nM
CP0275672
 Compound Info 
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C23H31N7O2
  1
1 IC50 = 325 nM
CP0074947
 Compound Info 
5-(6-bromo-5-methoxy-1H-indol-3-yl)-2-(1H-pyrrol-2-yl)-1,3-oxazole
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C16H12BrN3O2
  1
1 IC50 = 4600 nM
CP0074951
 Compound Info 
5-(6-bromo-4-methoxy-1H-indol-3-yl)-2-(1H-pyrrol-2-yl)-1,3-oxazole
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C16H12BrN3O2
  1
1 IC50 = 9600 nM
CP0074949
 Compound Info 
5-(6-bromo-4-methoxy-1H-indol-3-yl)-4-iodo-2-(1H-pyrrol-2-yl)-1,3-oxazole
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C16H11BrIN3O2
  1
1 IC50 > 10000 nM
CP0088278
 Compound Info 
5-(6-bromo-4-methoxy-1H-indol-3-yl)-2-(5-bromo-1H-pyrrol-2-yl)-1,3-oxazole
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C16H11Br2N3O2
  1
1 IC50 > 10000 nM
CP0568288
 Compound Info 
N-tert-butyl-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide
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C21H25N5O3
  1
1 Kd = 21 nM
Clinical Information about the Protein
Target 1 ( Cytoplasmic DRAK1 (STK17A) )
Target Type Literature-reported Target