General Information of the Protein
Protein ID
PT01126
Protein Name
Aurora kinase C
Secondarily
Protein Name
Aurora 3
Aurora/IPL1-related kinase 3
Aurora/IPL1/Eg2 protein 2
Serine/threonine-protein kinase 13
Serine/threonine-protein kinase aurora-C
Gene Name
AURKC
Secondarily
Gene Name
AIE2
AIK3
AIRK3
ARK3
STK13
Sequence
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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Other protein kinase group
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Other protein kinase AUR family
Function
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
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Uniprot ID
Primary ID:
Q9UQB9

Secondarily ID:
O60681
O75442
Q6AZY8
Q6DLZ0
Q9UPK5
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Ensembl ID
ENSG00000105146
HGNC ID
HGNC:11391
Subcellular Location
Nucleus
Chromosome
Chromosome
Centromere
Cytoplasm
Cytoskeleton
Spindle
Clinical Information about the Protein
Target 1 ( Aurora kinase C (AURKC) )
Target Type Clinical trial Target
Disease 4 Target-related Diseases  4
1 Haematological malignancy [ICD-11: 2B33.Y]
2 Prostate cancer [ICD-11: 2C82.0]
3 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
4 Advanced solid tumour [ICD-11: 2A00-2F9Z]
Clinical Trial Drug(s) 5 Clinical Trial Drugs  5
1 ABT-348 Phase 2
Haematological malignancy
2 PHA-739358 Phase 2
Prostate cancer
3 AMG 900 Phase 1
Solid tumour/cancer
4 GSK1070916 Phase 1
Advanced solid tumour
5 SNS-314 Phase 1
Solid tumour/cancer
Discontinued Drug(s) 1 Discontinued Drug  1
1 MK-6592 Discontinued in Phase 1
Solid tumour/cancer