General Information of the Protein
Protein ID
PT01060
Protein Name
Serine/threonine-protein kinase D3
Secondarily
Protein Name
Protein kinase C nu type
Protein kinase EPK2
nPKC-nu
Gene Name
PRKD3
Secondarily
Gene Name
EPK2
PRKCN
Sequence
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CAMK protein kinase group
>
CAMK protein kinase PKD family
Function
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
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Uniprot ID
Primary ID:
O94806

Secondarily ID:
D6W587
Q53TR7
Q8NEL8
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Ensembl ID
ENSG00000115825
HGNC ID
HGNC:9408
Subcellular Location
Cytoplasm
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0533915
 Compound Info 
2-[4-[[(2R)-2-aminobutyl]amino]pyrimidin-2-yl]-4-(1-methylpyrazol-4-yl)phenol
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C18H22N6O
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
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CP0485198
 Compound Info 
3-(1H-indol-3-yl)-1-(piperidin-4-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
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C19H21N7
  1
1
IC50 = 17 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0926275
 Compound Info 
3-(2-Ethoxyquinolin-6-yl)-1-((1-methylpiperidin-4-yl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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C23H27N7O
  1
1
IC50 = 43 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0533913
 Compound Info 
3-[4-amino-3-(1H-indol-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-2,2-dimethylpropan-1-ol
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C18H20N6O
  1
1
IC50 = 76 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0472472
 Compound Info 
3-naphthalen-1-yl-1-(piperidin-4-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
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C21H22N6
  1
1
IC50 = 78 nM
 Bioactivity Info 
   TI
   LI
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CP0472473
 Compound Info 
1-tert-butyl-3-(1H-indol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C17H18N6
  1
1
IC50 = 108 nM
 Bioactivity Info 
   TI
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CP0533914
 Compound Info 
1-tert-butyl-3-(1H-pyrrolo[3,2-b]pyridin-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C16H17N7
  1
1
IC50 = 456 nM
 Bioactivity Info 
   TI
   LI
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CP0016790
 Compound Info 
1-tert-butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
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C20H21N5
  1
1
IC50 = 616 nM
 Bioactivity Info 
   TI
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CP0485196
 Compound Info 
1-tert-butyl-3-(1-methylindol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C18H20N6
  1
1
IC50 = 4055 nM
 Bioactivity Info 
   TI
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   TS