General Information of the Protein
Protein ID
PT01039
Protein Name
Tissue factor
Secondarily
Protein Name
Coagulation factor III
Thromboplastin
Gene Name
F3
Sequence
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
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Uniprot ID
Primary ID:
P13726

Secondarily ID:
D3DT47
Q6FHG2
Q86WH4
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Ensembl ID
ENSG00000117525
HGNC ID
HGNC:3541
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000040 , THP-1
Compound ID Compound Name Compound Formula
CP0397821
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13bS)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylate
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C36H58O9
 1
1
IC50 = 0.028 nM
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CP0070806
CHEBI:67985
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C36H58O8
 1
1
IC50 = 0.035 nM
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CP0067553
(1E,4E)-1,5-Diphenyl-penta-1,4-dien-3-one
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C17H14O
 1
1
IC50 = 0.053 nM
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CP0454519
CHEBI:4747
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C30H48O4
 1
1
IC50 = 0.054 nM
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CP0516028
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13bS)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylate
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C36H58O8
 1
1
IC50 = 0.078 nM
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CP0465723
Vitalboside A
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C36H58O8
 1
1
IC50 = 0.095 nM
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CP0042353
(E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone
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C15H12O2
 1
1
IC50 = 0.12 nM
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CP0036897
(4aS,6aR,6aS,6bR,8aR,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
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C30H46O3
 1
1
IC50 = 0.221 nM
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CP0272224
4-Epi-Hederagenin
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C30H48O4
 1
1
IC50 = 0.221 nM
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CP0548992
(1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13bS)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
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C30H48O4
 1
1
IC50 = 0.221 nM
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CP0064551
2,6-Bis-(benzylidene)-cyclohexanone
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C20H18O
 1
1
IC50 = 0.26 nM
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CP0454520
CHEBI:67947
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C36H58O9
 1
1
IC50 = 0.28 nM
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CP0454517
[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13bS)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-9-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylate
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C42H68O13
 1
1
IC50 = 0.64 nM
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CP0454518
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aR,5R,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-5,10-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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C36H58O10
 1
1
IC50 = 0.801 nM
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CP0134951
2,6-bis(4-hydroxybenzylidene)cyclohexanone
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C20H18O3
 1
1
IC50 = 0.94 nM
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CP0036127
(E)-1,3-Bis-(4-hydroxy-phenyl)-propenone
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C15H12O3
 1
1
IC50 = 0.96 nM
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CP0432890
(4aS,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
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C30H48O4
 1
1
IC50 = 1.294 nM
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CP0064545
(1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-3-one
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C17H14O3
 1
1
IC50 = 2.58 nM
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CP0386126
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) (E)-3-phenylprop-2-enoate
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C28H25NO5
 1
1
IC50 = 3.75 nM
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CP0121045
(4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-benzyl 10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate
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C37H54O3
 1
1
IC50 = 4.678 nM
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CP0039971
NSC-114945
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C30H48O3
 1
1
IC50 = 4.975 nM
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CP0454521
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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C36H58O9
 1
1
IC50 = 6.46 nM
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CP0385104
(1R)-17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-ol
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C19H19NO4
 1
1
IC50 = 6.75 nM
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CP0151254
5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine
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C20H21NO4
 1
1
IC50 = 8.35 nM
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CP0424421
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[[(1R)-17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl]oxy]oxane-3,4,5-triol
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C25H29NO9
 1
1
IC50 = 8.79 nM
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CP0516030
[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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C42H68O14
 1
1
IC50 = 9.581 nM
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CP0566925
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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C36H58O9
 1
1
IC50 = 10.61 nM
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CP0097465
17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-ol
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C19H19NO4
 1
1
IC50 = 12.17 nM
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CP0470761
(2S,3R,4S,5S,6R)-2-[[(13aR)-2,3,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-9-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
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C26H33NO9
 1
1
IC50 = 12.61 nM
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CP0062008
CHEBI:3962
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C21H20O6
 1
1
IC50 = 13.16 nM
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CP0508304
(1E,4E)-1,5-bis(4-methoxyphenyl)penta-1,4-dien-3-one
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C19H18O3
 1
1
IC50 = 13.37 nM
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CP0054980
2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
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C21H25NO4
 1
1
IC50 = 14.98 nM
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CP0803801
1,3-bis(4-methoxyphenyl)prop-2-en-1-one
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C17H16O3
 1
1
IC50 = 15.39 nM
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CP0566926
[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
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C42H68O13
 1
1
IC50 = 15.95 nM
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CP0449190
(2S,3R,4S,5S,6R)-2-[[(13aS)-2,3,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-9-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
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C26H33NO9
 1
1
IC50 = 16.8 nM
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CP0230384
(-)-Tetrahydropalmatine
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C21H25NO4
 1
1
IC50 = 22.78 nM
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CP0440159
(1S)-17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-ol
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C19H19NO4
 1
1
IC50 = 36.41 nM
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CP0440860
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[[(1S)-17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl]oxy]oxane-3,4,5-triol
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C25H29NO9
 1
1
IC50 = 38.59 nM
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CP0419719
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) acetate
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C21H21NO5
 1
1
IC50 = 63.06 nM
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CP0089986
STEPHOLIDINE
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C19H21NO4
 1
1
IC50 = 104.58 nM
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CP0419718
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) propanoate
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C22H23NO5
 1
1
IC50 = 118.8 nM
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CP0303391
(E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
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C16H14O3
 1
1
IC50 = 141.98 nM
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CP0169939
(-)-Corydalmine
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C20H23NO4
 1
1
IC50 = 152.43 nM
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CP0420870
2,3,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-9-ol
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C20H23NO4
 1
1
IC50 = 187.26 nM
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CP0003494
US9187397, 1 (curcumin)
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C21H20O6
 1
1
IC50 = 199.63 nM
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CP0427611
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) (E)-3-(4-acetyloxy-3-methoxyphenyl)prop-2-enoate
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C31H29NO8
 1
1
IC50 = 201.93 nM
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CP0481440
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) benzoate
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C26H23NO5
 1
1
IC50 = 376.52 nM
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CP0538345
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) 2-acetyloxybenzoate
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C28H25NO7
 1
1
IC50 = 555.37 nM
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CP0420786
9,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,3-diol
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C19H21NO4
 1
1
IC50 = 968.9 nM
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CP0538346
(17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-16-yl) hexanoate
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C25H29NO5
 1
1
IC50 = 1501.43 nM
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CP0015639
(1E,4E)-1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one
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C19H18O5
 1
1
IC50 > 200 nM
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CP0065128
(2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone
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C22H22O5
 1
1
IC50 > 200 nM
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CP0090873
2,6-bis(4-methoxybenzylidene)cyclohexanone
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C22H22O3
 1
1
IC50 > 200 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0005479
CHEBI:46024
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C17H22N2O3
 1
1 IC50 = 50 nM
Clinical Information about the Protein
Target 1 ( Tissue factor (F3) )
Target Type Successful Target