General Information of the Protein
Protein ID
PT01034
Protein Name
Phosphatidylinositol 4-kinase beta
Secondarily
Protein Name
NPIK
PI4K92
PI4KIII
Gene Name
PI4KB
Secondarily
Gene Name
PIK4CB
Sequence
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development.
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Uniprot ID
Primary ID:
Q9UBF8

Secondarily ID:
B4DGI2
O15096
P78405
Q5VWB9
Q5VWC0
Q5VWC1
Q9BWR6
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Ensembl ID
ENSG00000143393
HGNC ID
HGNC:8984
Subcellular Location
Endomembrane system
Mitochondrion outer membrane
Rough endoplasmic reticulum membrane
Golgi apparatus
Golgi apparatus membrane
Cytoplasm
Perinuclear region
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0517645
 Compound Info 
3-[[4-[2-(2,2-dimethylpropanoylamino)-4-methyl-1,3-thiazol-5-yl]-1,3-thiazol-2-yl]amino]benzoic acid
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C19H20N4O3S2
  1
1
IC50 = 90 nM
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CP0466727
 Compound Info 
N-[4-(2-acetamido-4-methyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]prop-2-enamide
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C12H12N4O2S2
  3
1
IC50 = 140 nM
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2
IC50 = 570 nM
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3
IC50 = 2160 nM
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CP0109622
 Compound Info 
4-[[[6-[1-(cyclopropylmethyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]amino]methyl]cyclohexane-1-carboxylic acid
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C24H27N3O3S
  1
1
IC50 = 251.19 nM
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CP0058429
 Compound Info 
1-(cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
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C23H27N3O2S
  1
1
IC50 = 316.23 nM
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CP0058431
 Compound Info 
6-[6-(methoxymethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
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C14H13N3OS
  1
1
IC50 = 316.23 nM
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CP0058995
 Compound Info 
4-(2-amino-1,3-benzothiazol-6-yl)-1-ethylpyridin-2-one
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C14H13N3OS
  1
1
IC50 = 316.23 nM
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CP0071821
 Compound Info 
4-(2-amino-1,3-benzothiazol-6-yl)-1-methylpyridin-2-one
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C13H11N3OS
  1
1
IC50 = 316.23 nM
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CP0066812
 Compound Info 
1-(cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-one
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C22H25N3O2S
  1
1
IC50 = 398.11 nM
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CP0059000
 Compound Info 
6-(6-methylpyridin-3-yl)-1,3-benzothiazol-2-amine
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C13H11N3S
  1
1
IC50 = 501.19 nM
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CP0066807
 Compound Info 
6-phenyl-1,3-benzothiazol-2-amine
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C13H10N2S
  1
1
IC50 = 501.19 nM
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CP0141572
 Compound Info 
2-[5-(2-amino-1,3-benzothiazol-6-yl)pyridin-2-yl]oxyethanol
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C14H13N3O2S
  1
1
IC50 = 501.19 nM
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CP0491667
 Compound Info 
N-[5-[2-[3-acetyl-N-(2-hydroxyethyl)anilino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
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C19H20N4O3S2
  1
1
IC50 = 600 nM
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CP0058998
 Compound Info 
1-(cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one
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C22H25N3O3S2
  1
1
IC50 = 630.96 nM
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CP0066763
 Compound Info 
6-(6-ethylsulfanylpyridin-3-yl)-1,3-benzothiazol-2-amine
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C14H13N3S2
  1
1
IC50 = 630.96 nM
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CP0066814
 Compound Info 
4-(2-amino-1,3-benzothiazol-6-yl)-1H-pyridin-2-one
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C12H9N3OS
  1
1
IC50 = 630.96 nM
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CP0071820
 Compound Info 
6-(6-ethoxypyridin-3-yl)-1,3-benzothiazol-2-amine
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C14H13N3OS
  1
1
IC50 = 630.96 nM
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CP0072106
 Compound Info 
6-pyridin-3-yl-1,3-benzothiazol-2-amine
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C12H9N3S
  1
1
IC50 = 630.96 nM
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CP0445795
 Compound Info 
N-[5-[2-(2-hydroxyethylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
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C14H20N4O2S2
  1
1
IC50 = 730 nM
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CP0071824
 Compound Info 
[5-(2-amino-1,3-benzothiazol-6-yl)pyridin-2-yl]methanol
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C13H11N3OS
  1
1
IC50 = 794.33 nM
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CP0177911
 Compound Info 
6-(1-benzylpyrazol-4-yl)-1,3-benzothiazol-2-amine
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C17H14N4S
  1
1
IC50 = 794.33 nM
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CP0038494
 Compound Info 
6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine
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C13H11N3OS
  1
1
IC50 = 1000 nM
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CP0059004
 Compound Info 
6-(pyridin-4-yl)benzo[d]thiazol-2-amine
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C12H9N3S
  1
1
IC50 = 1000 nM
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CP0066804
 Compound Info 
6-[6-(ethylamino)pyridin-3-yl]-1,3-benzothiazol-2-amine
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C14H14N4S
  1
1
IC50 = 1000 nM
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CP0066806
 Compound Info 
6-(5-propan-2-yloxypyridin-3-yl)-1,3-benzothiazol-2-amine
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C15H15N3OS
  1
1
IC50 = 1000 nM
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CP0141585
 Compound Info 
6-(2-methylpyrazol-3-yl)-1,3-benzothiazol-2-amine
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C11H10N4S
  1
1
IC50 = 1000 nM
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CP0155758
 Compound Info 
6-[6-(2-methoxyethoxy)pyridin-3-yl]-1,3-benzothiazol-2-amine
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C15H15N3O2S
  1
1
IC50 = 1000 nM
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CP0141586
 Compound Info 
6-(1-methylpyrazol-4-yl)-1,3-benzothiazol-2-amine
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C11H10N4S
  1
1
IC50 = 1258.93 nM
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CP0175247
 Compound Info 
6-(1-methylpyrazol-3-yl)-1,3-benzothiazol-2-amine
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C11H10N4S
  1
1
IC50 = 1258.93 nM
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CP0178134
 Compound Info 
6-(6-propan-2-yloxypyridin-3-yl)-1,3-benzothiazol-2-amine
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C15H15N3OS
  1
1
IC50 = 1258.93 nM
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CP0477125
 Compound Info 
tert-butyl N-[5-[2-(2-hydroxyethylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]carbamate
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C14H20N4O3S2
  1
1
IC50 = 1360 nM
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CP0491668
 Compound Info 
N-[5-[2-(2-hydroxyethylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide
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C16H16N4O2S2
  1
1
IC50 = 1540 nM
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CP0058999
 Compound Info 
6-[6-[ethyl(methyl)amino]pyridin-3-yl]-1,3-benzothiazol-2-amine
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C15H16N4S
  1
1
IC50 = 1584.89 nM
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CP0065579
 Compound Info 
6-(1-ethylpyrazol-4-yl)-1,3-benzothiazol-2-amine
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C12H12N4S
  1
1
IC50 = 1584.89 nM
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CP0065581
 Compound Info 
6-[6-(trifluoromethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
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C13H8F3N3S
  1
1
IC50 = 1584.89 nM
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CP0071822
 Compound Info 
4-(2-amino-1,3-benzothiazol-6-yl)-1-(cyclopropylmethyl)pyridin-2-one
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C16H15N3OS
  1
1
IC50 = 1584.89 nM
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CP0481790
 Compound Info 
N-[4-(2-acetamido-4-methyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]-2-bromoacetamide
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C11H11BrN4O2S2
  3
1
IC50 = 1670 nM
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2
IC50 = 1710 nM
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3
IC50 = 2110 nM
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CP0059006
 Compound Info 
6-(1-cyclopropylpyrazol-4-yl)-1,3-benzothiazol-2-amine
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C13H12N4S
  1
1
IC50 = 1995.26 nM
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CP0072116
 Compound Info 
6-[1-(cyclopropylmethyl)pyrazol-4-yl]-1,3-benzothiazol-2-amine
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C14H14N4S
  1
1
IC50 = 1995.26 nM
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CP0141588
 Compound Info 
6-(1-propylpyrazol-4-yl)-1,3-benzothiazol-2-amine
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C13H14N4S
  1
1
IC50 = 1995.26 nM
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CP0445794
 Compound Info 
N-[5-[2-[3-acetyl-N-(2-hydroxyethyl)anilino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
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C22H26N4O3S2
  1
1
IC50 = 2100 nM
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CP0058996
 Compound Info 
1-(cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
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C23H27N3O2S
  1
1
IC50 = 2511.89 nM
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CP0059003
 Compound Info 
6-pyridin-2-yl-1,3-benzothiazol-2-amine
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C12H9N3S
  1
1
IC50 = 2511.89 nM
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CP0066809
 Compound Info 
6-(1-propan-2-ylpyrazol-4-yl)-1,3-benzothiazol-2-amine
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C13H14N4S
  1
1
IC50 = 2511.89 nM
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CP0154374
 Compound Info 
5-(2-amino-1,3-benzothiazol-6-yl)-N-methylpyridine-2-carboxamide
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C14H12N4OS
  1
1
IC50 = 2511.89 nM
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CP0068463
 Compound Info 
6-[6-(methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
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C14H14N4S
  1
1
IC50 = 3162.28 nM
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CP0445796
 Compound Info 
N-[5-[2-[cyclohexyl(2-hydroxyethyl)amino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
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C20H30N4O2S2
  1
1
IC50 = 3400 nM
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CP0058993
 Compound Info 
5-(2-amino-1,3-benzothiazol-6-yl)-1H-pyridin-2-one
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C12H9N3OS
  1
1
IC50 = 3981.07 nM
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CP0059002
 Compound Info 
6-(5-methylsulfonylpyridin-3-yl)-1,3-benzothiazol-2-amine
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C13H11N3O2S2
  1
1
IC50 = 3981.07 nM
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CP0477148
 Compound Info 
N-[5-[2-(2-hydroxyethylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
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C11H14N4O2S2
  1
1
IC50 = 4500 nM
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CP0402074
 Compound Info 
(E)-N-[4-(2-acetamido-4-methyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]-4-methylpent-2-enamide
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C15H18N4O2S2
  3
1
IC50 = 4840 nM
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2
IC50 = 5580 nM
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3
IC50 = 17400 nM
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CP0450706
 Compound Info 
N-[4-(2-acetamido-4-methyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]propanamide
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C12H14N4O2S2
  3
1
IC50 = 5210 nM
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2
IC50 = 5390 nM
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3
IC50 = 5580 nM
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CP0550889
 Compound Info 
3-[[4-[2-(2,2-dimethylpropanoylamino)-4-methyl-1,3-thiazol-5-yl]-1,3-thiazol-2-yl]amino]propanoic acid
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C15H20N4O3S2
  1
1
IC50 = 5460 nM
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CP0532475
 Compound Info 
N-[5-[2-[cyclohexyl(2-hydroxyethyl)amino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
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C17H24N4O2S2
  1
1
IC50 = 5800 nM
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CP0058990
 Compound Info 
6-pyrimidin-2-yl-1,3-benzothiazol-2-amine
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C11H8N4S
  1
1
IC50 = 6309.57 nM
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CP0058991
 Compound Info 
6-pyrazin-2-yl-1,3-benzothiazol-2-amine
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C11H8N4S
  1
1
IC50 = 6309.57 nM
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CP0567437
 Compound Info 
4-[[4-[2-(2,2-dimethylpropanoylamino)-4-methyl-1,3-thiazol-5-yl]-1,3-thiazol-2-yl]amino]butanoic acid
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C16H22N4O3S2
  1
1
IC50 = 6980 nM
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CP0141584
 Compound Info 
6-(6-methylsulfonylpyridin-3-yl)-1,3-benzothiazol-2-amine
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C13H11N3O2S2
  1
1
IC50 = 7943.28 nM
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CP0445894
 Compound Info 
N-[5-[2-(cyclohexylamino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
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C15H20N4OS2
  1
1
IC50 = 8290 nM
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CP0458180
 Compound Info 
N-[5-[2-[cyclohexyl(methyl)amino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
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C16H22N4OS2
  1
1
IC50 = 9520 nM
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CP0445797
 Compound Info 
2-[[4-[2-(2,2-dimethylpropanoylamino)-4-methyl-1,3-thiazol-5-yl]-1,3-thiazol-2-yl]amino]acetic acid
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C14H18N4O3S2
  1
1
IC50 = 9930 nM
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CP0066815
 Compound Info 
4-(2-amino-1,3-benzothiazol-6-yl)-1-(2-methoxyethoxy)pyridin-2-one
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C15H15N3O3S
  1
1
IC50 = 10000 nM
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CP0402073
 Compound Info 
N-[4-methyl-5-[2-[(4-methylcyclohexyl)amino]-1,3-thiazol-4-yl]-1,3-thiazol-2-yl]acetamide
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C16H22N4OS2
  1
1
IC50 = 14160 nM
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CP0093334
 Compound Info 
5-(2-amino-1,3-benzothiazol-6-yl)-N,N-dimethylpyridine-2-carboxamide
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C15H14N4OS
  1
1
IC50 = 39810.72 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Phosphatidylinositol-4-kinase beta (PI4KB) )
Target Type Clinical trial Target