General Information of the Protein
Protein ID
PT00963
Protein Name
Coagulation factor VII
Secondarily
Protein Name
Proconvertin
Serum prothrombin conversion accelerator
Gene Name
F7
Sequence
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease PA clan
>
Serine protease S1A subfamily
Function
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
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Uniprot ID
Primary ID:
P08709

Secondarily ID:
B0YJC8
Q14339
Q5JVF1
Q5JVF2
Q9UD52
Q9UD53
Q9UD54
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HGNC ID
HGNC:3544
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000051 , BHK-21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0203139
 Compound Info 
(2R)-7-cyclopropylsulfonyl-4,17,20-trimethyl-2-[(1-oxo-2H-isoquinolin-7-yl)amino]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dione
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C33H34N4O6S
  1
1
Ki = 4.2 nM
 Bioactivity Info 
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CP0534211
 Compound Info 
2-[(2R,5R)-17,20-dimethyl-3,12-dioxo-2-[(1-oxo-2H-isoquinolin-7-yl)amino]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaen-5-yl]acetic acid
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C31H30N4O6
  1
1
Ki = 9.6 nM
 Bioactivity Info 
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CP0476604
 Compound Info 
(2R)-7-ethylsulfonyl-4-methyl-2-[(1-oxo-2H-isoquinolin-7-yl)amino]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dione
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C30H30N4O6S
  1
1
Ki = 61 nM
 Bioactivity Info 
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CP0534552
 Compound Info 
3-[[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-propan-2-ylsulfanyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaen-2-yl]amino]benzamide
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C31H36N4O4S
  1
1
Ki = 91 nM
 Bioactivity Info 
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CP0558573
 Compound Info 
ethyl 2-[(2R,5R)-17,20-dimethyl-3,12-dioxo-2-[(1-oxo-2H-isoquinolin-7-yl)amino]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaen-5-yl]acetate
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C33H34N4O6
  1
1
Ki = 360 nM
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CP0476605
 Compound Info 
(2R,8R)-20,23-dimethyl-2-[(1-oxo-2H-isoquinolin-7-yl)amino]-16-oxa-4,14-diazatetracyclo[17.2.2.19,13.04,8]tetracosa-1(22),9(24),10,12,19(23),20-hexaene-3,15-dione
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C32H32N4O4
  1
1
Ki = 840 nM
 Bioactivity Info 
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CP0454480
 Compound Info 
3-[[(2R)-4-methyl-3,12-dioxo-7-propan-2-ylsulfonyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaen-2-yl]amino]benzamide
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C29H32N4O6S
  1
1
Ki = 940 nM
 Bioactivity Info 
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CP0465819
 Compound Info 
4,17,20-trimethyl-2-[(1-oxo-2H-isoquinolin-7-yl)amino]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaene-3,12-dione
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C30H30N4O4
  1
1
Ki = 1500 nM
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CP0541571
 Compound Info 
3-[(17,20-diethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl)amino]benzamide
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C29H32N4O4
  1
1
Ki = 2100 nM
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CP0548151
 Compound Info 
3-[(17-ethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl)amino]benzamide
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C27H28N4O4
  1
1
Ki = 9200 nM
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CP0454481
 Compound Info 
3-[(3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaen-2-yl)amino]benzamide
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C25H24N4O4
  1
1
Ki > 10000 nM
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Clinical Information about the Protein
Target 1 ( Coagulation factor VII (F7) )
Target Type Successful Target