General Information of the Protein
Protein ID
PT00501
Protein Name
Urotensin-2 receptor
Secondarily
Protein Name
Urotensin II receptor
Gene Name
UTS2R
Sequence
MALSPAPLSGFPEPSAAPNASLNRSWASPTEPSSLEDLVATGAIGAVLSAMGVVGVAGNAYTLVVMCRVLHTSASMSVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFSLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRSKGYRKVLALGTWLLALLLALPMMLAIRLVHRGHKSLCLPVWGPRAHRAYLTLLFGTSIVGPGTVIGLLYVRLARAYWLSQRASFTQTRRLPNPKVLYLILGIVLLFWACFLPFWLWQLLAQYRGAQTLTPRTARIVNYLTTCLTYGNSCVNPFLYTLLTKNYREYRRRSLRARSARGPAGARHSLPCRVRFQRGSGHSLCSSSQQATETITLSPAASRAVCA
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Organism
Felis catus, Cat, Felis silvestris catus
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neuropeptide receptor
Function
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
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Uniprot ID
Primary ID:
Q533H1

Secondarily ID:
M3WUV0
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Subcellular Location
Cell membrane
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0525989
 Compound Info 
N-hexyl-5H-pyrido[4,3-b]indol-1-amine
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C17H21N3
  1
1
Ki = 199.53 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398931
 Compound Info 
N-pentyl-5H-pyrido[4,3-b]indol-1-amine
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C16H19N3
  1
1
Ki = 398.11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138744
 Compound Info 
N-butyl-5H-pyrido[4,3-b]indol-1-amine
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C15H17N3
  1
1
Ki = 630.96 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0491860
 Compound Info 
N-butyl-5-methylpyrido[4,3-b]indol-1-amine
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C16H19N3
  1
1
Ki = 630.96 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0372287
 Compound Info 
N-benzyl-5H-pyrido[4,3-b]indol-1-amine
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C18H15N3
  1
1
Ki = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519726
 Compound Info 
N-(thiophen-2-ylmethyl)-5H-pyrido[4,3-b]indol-1-amine
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C16H13N3S
  1
1
Ki = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0491861
 Compound Info 
N-(2-methylbutyl)-5H-pyrido[4,3-b]indol-1-amine
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C16H19N3
  1
1
Ki = 1258.93 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0458877
 Compound Info 
N-(3-methylbutyl)-5H-pyrido[4,3-b]indol-1-amine
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C16H19N3
  1
1
Ki = 1584.89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0455294
 Compound Info 
N-(cyclopropylmethyl)-5H-pyrido[4,3-b]indol-1-amine
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C15H15N3
  1
1
Ki = 2511.89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02463 Urotensin-2 receptor Homo sapiens, Human
 Protein Info