Brief Information of the Cell Line and Protein
Cell Line ID: CL000196 , MDA-MB-468
 Cell Line Info 
Synonyms
MDA-MB 468
MDA-MB468
MDAMB468
MDA-468
MDA468
MB468
MD Anderson-Metastatic Breast-468
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0419
Protein ID: PT05157 , Acetyl-coenzyme A synthetase, cytoplasmic
 Protein Info 
Gene Name ACSS2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID Q9NR19
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000196
 Cell Line Info 
 Protein ID: PT05157
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0491794
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-1-[4-(difluoromethoxy)-3-pyridin-3-ylphenyl]-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C25H20F4N4O3
  1
1
IC50 = 0.33 nM
 Bioactivity Info 
   TI
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CP0558527
 Compound Info 
N-[3-(1,1-difluoropropyl)phenyl]-1-(4-methoxyphenyl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C21H21F2N3O3
  1
1
IC50 = 0.4626 nM
 Bioactivity Info 
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CP0558526
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-1-(3,4-dimethoxyphenyl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C21H21F2N3O4
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0424251
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-1-[4-methoxy-3-(1,3-oxazol-2-yl)phenyl]-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C23H20F2N4O4
  1
1
IC50 = 1.1 nM
 Bioactivity Info 
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CP0577967
 Compound Info 
methyl 3-[4-[[3-(furan-2-yl)phenyl]carbamoyl]-3-methyl-5-oxo-4H-pyrazol-1-yl]benzoate
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C23H19N3O5
  1
1
IC50 = 2.1 nM
 Bioactivity Info 
   TI
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CP0533284
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-1-[4-(difluoromethoxy)phenyl]-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C20H17F4N3O3
  1
1
IC50 = 2.66 nM
 Bioactivity Info 
   TI
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CP0440689
 Compound Info 
N-[3-(furan-2-yl)phenyl]-1-(4-methoxyphenyl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C22H19N3O4
  1
1
IC50 = 3.2 nM
 Bioactivity Info 
   TI
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CP0577965
 Compound Info 
N-[3-(furan-2-yl)phenyl]-1-(6-methoxypyridin-3-yl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C21H18N4O4
  1
1
IC50 = 3.9 nM
 Bioactivity Info 
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CP0533283
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-3-methyl-5-oxo-1-phenyl-4H-pyrazole-4-carboxamide
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C19H17F2N3O2
  1
1
IC50 = 4 nM
 Bioactivity Info 
   TI
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CP0577966
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-1-(4-methoxyphenyl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C20H19F2N3O3
  1
1
IC50 = 4.5 nM
 Bioactivity Info 
   TI
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CP0435215
 Compound Info 
N-[3-(1,1-difluoroethyl)phenyl]-1-(6-methoxypyridin-3-yl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide
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C19H18F2N4O3
  1
1
IC50 = 5 nM
 Bioactivity Info 
   TI
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