Brief Information of the Cell Line and Protein
Cell Line ID: CL000314 , HEK293T/17
 Cell Line Info 
Synonyms
HEK-293T/17
HEK 293T/17
293T/17
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1926
Protein ID: PT05076 , Replicase polyprotein 1ab
 Protein Info 
Gene Name REP
Organism Severe acute respiratory syndrome coronavirus 2, 2019-nCoV, SARS-CoV-2
Protein Classification Enzyme
Uniprot ID P0DTD1
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000314
 Cell Line Info 
 Protein ID: PT05076
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0571038
 Compound Info 
benzyl N-[(2S,3R)-1-[[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C32H48N4O7
  1
1
EC50 = 30 nM
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CP0576124
 Compound Info 
benzyl N-[(2S,3R)-1-[[(2S)-4,4-dimethyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C30H46N4O7
  1
1
EC50 = 56 nM
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CP0575684
 Compound Info 
benzyl N-[(2S,3R)-1-[[(2S)-3-cyclopropyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C29H42N4O7
  1
1
EC50 = 97 nM
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CP0571765
 Compound Info 
benzyl N-[(2S,3R)-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C29H44N4O7
  1
1
EC50 = 120 nM
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CP0574987
 Compound Info 
(3-chlorophenyl)methyl N-[(2S,3R)-1-[[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C32H47ClN4O7
  1
1
EC50 = 140 nM
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CP0562976
 Compound Info 
benzyl N-[(2S,3R)-1-[(1R,2S,5S)-6,6-dimethyl-2-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl]-3-azabicyclo[3.1.0]hexan-3-yl]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C31H44N4O7
  1
1
EC50 = 140 nM
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CP0579550
 Compound Info 
benzyl N-[(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-1-oxo-1-[[(2S)-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate
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C32H42N4O7
  1
1
EC50 = 190 nM
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CP0567955
 Compound Info 
(3-chlorophenyl)methyl N-[(2S,3R)-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate
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C29H43ClN4O7
  1
1
EC50 = 230 nM
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CP0543218
 Compound Info 
benzyl N-[(2S)-1-[(1R,2S,5S)-6,6-dimethyl-2-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl]-3-azabicyclo[3.1.0]hexan-3-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C29H40N4O6
  1
1
EC50 = 310 nM
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CP0543501
 Compound Info 
tert-butyl N-[(2S)-1-[(1R,2S,5S)-6,6-dimethyl-2-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl]-3-azabicyclo[3.1.0]hexan-3-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C26H42N4O6
  1
1
EC50 = 370 nM
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CP0576126
 Compound Info 
(3-chlorophenyl)methyl N-[(2S)-1-[[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C29H41ClN4O6
  1
1
EC50 = 630 nM
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CP0575566
 Compound Info 
MPI5
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C29H42N4O6
  1
1
EC50 = 660 nM
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CP0488226
 Compound Info 
(2S,3R)-2-(tert-butylcarbamoylamino)-N-[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-3-[(2-methylpropan-2-yl)oxy]butanamide
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C29H51N5O6
  1
1
EC50 = 740 nM
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CP0579549
 Compound Info 
benzyl N-[(2S)-1-[[(2S)-4,4-dimethyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C28H42N4O6
  1
1
EC50 = 860 nM
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CP0551673
 Compound Info 
benzyl N-[(2S)-1-[[(2S)-3-cyclopropyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
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C27H38N4O6
  1
1
EC50 = 1500 nM
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CP0562974
 Compound Info 
(1R,2S,5S)-3-[(2S)-3,3-dimethyl-2-(3-methylbutanoylamino)butanoyl]-6,6-dimethyl-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C26H42N4O5
  1
1
EC50 = 2600 nM
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CP0571767
 Compound Info 
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3R)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C23H32F3N5O4
  1
1
EC50 = 3400 nM
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CP0572027
 Compound Info 
PF-07321332
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C23H32F3N5O4
  1
1
EC50 = 3400 nM
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CP0568656
 Compound Info 
(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C26H43N5O5
  1
1
EC50 = 5000 nM
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CP0568642
 Compound Info 
(1R,2S,5S)-3-[(2S)-2-(3,3-dimethylbutanoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C27H44N4O5
  1
1
EC50 = 7400 nM
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CP0562973
 Compound Info 
(1R,2S,5S)-N-[(2S)-4-amino-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3-[(2S)-2-(3,3-dimethylbutanoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C28H45N5O6
  1
1
EC50 = 7700 nM
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CP0576823
 Compound Info 
benzyl N-[1-[[(2S)-4,4-dimethyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]carbamate
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C26H38N4O6
  1
1
EC50 > 10000 nM
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CP0577497
 Compound Info 
benzyl N-[1-[[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]carbamoyl]cyclopropyl]carbamate
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C28H38N4O6
  1
1
EC50 > 10000 nM
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CP0966340
 Compound Info 
N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-1H-indole-2-carboxamide
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C27H37N5O5
  1
1
EC50 > 10000 nM
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CP0027204
 Compound Info 
(1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide
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C27H45N5O5
  1
1
EC50 > 10000 nM
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CP0543097
 Compound Info 
(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C30H48N6O6
  1
1
EC50 > 10000 nM
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CP0543098
 Compound Info 
(6S)-5-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-5-azaspiro[2.4]heptane-6-carboxamide
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C25H41N5O5
  1
1
EC50 > 10000 nM
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CP0562969
 Compound Info 
(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-4-(ethylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C29H48N6O6
  1
1
EC50 > 10000 nM
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CP0569591
 Compound Info 
(2S)-2-(tert-butylcarbamoylamino)-N-[(2S)-3-cyclopropyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-3,3-dimethylbutanamide
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C24H41N5O5
  1
1
EC50 > 10000 nM
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CP0570192
 Compound Info 
(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-4-(cyclopropylmethylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C31H50N6O6
  1
1
EC50 > 10000 nM
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CP0570193
 Compound Info 
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-2-(3,3-dimethylbutanoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C27H43N5O4
  1
1
EC50 > 10000 nM
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CP0575193
 Compound Info 
(1R,2S,5S)-N-[(2S)-4-(butylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C31H52N6O6
  1
1
EC50 > 10000 nM
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CP0575683
 Compound Info 
(1R,2S,5S)-N-[(2S)-4-(benzylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C34H50N6O6
  1
1
EC50 > 10000 nM
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CP0576141
 Compound Info 
(1R,2S,5S)-N-[(2S)-4-amino-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C27H44N6O6
  1
1
EC50 > 10000 nM
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CP0543487
 Compound Info 
benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pent-4-en-2-yl]amino]-1-oxobutan-2-yl]carbamate
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C26H36N4O6
  1
1
EC50 > 2000 nM
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CP0543488
 Compound Info 
benzyl N-[(1S)-1-cyclopropyl-2-[[(2S)-4,4-dimethyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-2-oxoethyl]carbamate
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C27H38N4O6
  1
1
EC50 > 2000 nM
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CP0543494
 Compound Info 
benzyl N-[(2S)-1-[[(2S)-4,4-dimethyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C27H40N4O6
  1
1
EC50 > 2000 nM
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CP0544807
 Compound Info 
benzyl N-[(2S)-1-[[(2S)-3-cyclopropyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C26H36N4O6
  1
1
EC50 > 2000 nM
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CP0551670
 Compound Info 
benzyl N-[(1S)-1-cyclopropyl-2-[[(2S)-3-cyclopropyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-2-oxoethyl]carbamate
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C26H34N4O6
  1
1
EC50 > 2000 nM
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CP0551674
 Compound Info 
WO2006061714, P39.1
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C26H38N4O6
  1
1
EC50 > 2000 nM
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CP0569218
 Compound Info 
benzyl N-[(2S)-1-[[(2S)-4,4-dimethyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-2,3-dimethyl-1-oxobutan-2-yl]carbamate
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C28H42N4O6
  1
1
EC50 > 2000 nM
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CP0576125
 Compound Info 
benzyl N-[(2S)-1-[[(2S)-3-(furan-2-yl)-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
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C27H34N4O7
  1
1
EC50 > 2000 nM
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CP0576128
 Compound Info 
MPI4
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C29H36N4O6
  1
1
EC50 > 2000 nM
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CP0965328
 Compound Info 
(2R)-2-((R)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
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C21H30N3NaO8S
  1
1
EC50 > 2000 nM
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CP0562971
 Compound Info 
(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-4-(hexylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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C33H56N6O6
  1
1
EC50 > 5000 nM
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CP0576158
 Compound Info 
(2S)-2-[[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]amino]-4,4-dimethyl-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]pentanamide
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C25H45N5O5
  1
1
EC50 > 5000 nM
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