Brief Information of the Cell Line and Protein
Cell Line ID: CL000361 , C2C12
Synonyms
C2c12
C2-C12
C12
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0188
Protein ID: PT02560 , Diacylglycerol O-acyltransferase 1
Gene Name DGAT1
Organism Mus musculus, Mouse
Protein Classification Enzyme
Uniprot ID Q9Z2A7
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000361  Protein ID: PT02560
 
Compound ID Compound Name Compound Formula
CP0440068
2-[4-[4-[5-[(2-ethyl-4-methyl-1,3-oxazole-5-carbonyl)amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid
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C26H29N3O4
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0455441
2-[4-[4-[5-[(5-cyclobutyl-1,3,4-thiadiazol-2-yl)amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid
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C25H28N4O2S
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0391157
2-[4-[4-[4-[(5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino]phenyl]phenyl]-2-oxabicyclo[2.2.2]octan-1-yl]acetic acid
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C27H29N3O4
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0462265
2-[4-[4-[5-[(5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid
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C25H28N4O3
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0391156
2-[4-[4-[5-[(5-ethyl-1,3,4-oxadiazol-2-yl)amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid
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C23H26N4O3
 1
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
CP0479246
2-[4-[4-[4-[(2-ethyl-4-methyl-1,3-oxazole-5-carbonyl)amino]phenyl]phenyl]-2-oxabicyclo[2.2.2]octan-1-yl]acetic acid
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C28H30N2O5
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0455442
LCQ-908-NXA
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C25H24F3N3O2
 1
1
EC50 = 71 nM
   TI
   LI
   LO
   TS
CP0411042
2-[4-[4-[5-[(2-ethyl-4-methyl-1,3-oxazole-5-carbonyl)amino]pyridin-2-yl]phenyl]-2-oxabicyclo[2.2.2]octan-1-yl]acetic acid
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C27H29N3O5
 1
1
EC50 = 98 nM
   TI
   LI
   LO
   TS
CP0462264
2-[4-[4-[5-[(5-methyl-1,3,4-oxadiazol-2-yl)amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid
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C22H24N4O3
 1
1
EC50 = 206 nM
   TI
   LI
   LO
   TS
CP0459254
2-[4-[4-[5-[(5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino]pyridin-2-yl]phenyl]-2-oxabicyclo[2.2.2]octan-1-yl]acetic acid
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C26H28N4O4
 1
1
EC50 = 413 nM
   TI
   LI
   LO
   TS
CP0533414
2-[1-[4-[5-[(5-propan-2-yl-1,3,4-oxadiazol-2-yl)amino]pyridin-2-yl]phenyl]piperidin-4-yl]acetic acid
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C23H27N5O3
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0485296
N-[2-[[1-phenyl-3-(trifluoromethyl)pyrazole-4-carbonyl]amino]ethyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
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C21H17F6N5O3
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0383423
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-1-phenyl-3-(trifluoromethyl)pyrazole-4-carboxamide
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C22H21F3N4O3
 1
1
IC50 = 77 nM
   TI
   LI
   LO
   TS
CP0519371
6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpyrazol-4-yl]carbonyl}amino)ethyl]pyridine-3-carboxamide
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C21H20F3N5O3
 1
1
IC50 = 87 nM
   TI
   LI
   LO
   TS
CP0462722
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-1-pyridin-2-yl-3-(trifluoromethyl)pyrazole-4-carboxamide
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C21H20F3N5O3
 1
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
CP0453586
N-(3,4-dimethylphenyl)-2-(4-methoxy-2,6-dimethylphenyl)-3H-benzimidazole-5-carboxamide
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C25H25N3O2
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0244107
3-[4-[6-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1H-benzimidazol-2-yl]-3,5-dimethylphenyl]-2,2-dimethylpropanoic acid
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C29H28N4O4
 1
1
IC50 = 151 nM
   TI
   LI
   LO
   TS
CP0513574
3-[4-[6-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1H-benzimidazol-2-yl]-3,5-dimethylphenyl]propanoic acid
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C27H24N4O4
 1
1
IC50 = 181 nM
   TI
   LI
   LO
   TS
CP0485297
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-3-methyl-1-phenylpyrazole-4-carboxamide
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C22H24N4O3
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0401552
6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpyrazol-4-yl]carbonyl}amino)ethyl]pyridine-3-carboxamide
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C19H15ClF3N5O2
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0485295
1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}ethyl)-3-(trifluoromethyl)-1Hpyrazole-4-carboxamide
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C24H25F3N4O4
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0443584
3-[4-[6-[(4-tert-butylphenyl)carbamoyl]-1H-benzimidazol-2-yl]-3,5-dimethylphenyl]propanoic acid
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C29H31N3O3
 1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
CP0910947
1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbonyl}amino)ethyl]-3-(trifluoromethyl)-1Hpyrazole-4-carboxamide hydrochloride
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C23H20ClF3N6O2
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0502365
1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}ethyl)-3-(trifluoromethyl)-1Hpyrazole-4-carboxamide
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C24H25F3N4O4
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0374310
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-1-(2-hydroxyphenyl)-3-(trifluoromethyl)pyrazole-4-carboxamide
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C22H21F3N4O4
 1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
CP0510120
1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-ethyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide
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C22H27F3N4O3
 1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0497302
1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-ethyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide
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C23H23F3N4O3
 1
1
IC50 = 770 nM
   TI
   LI
   LO
   TS
CP0513575
3-[3,5-dimethyl-4-[6-(quinolin-2-ylcarbamoyl)-1H-benzimidazol-2-yl]phenyl]propanoic acid
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C28H24N4O3
 1
1
IC50 = 913 nM
   TI
   LI
   LO
   TS
CP0547900
3-[3,5-dimethyl-4-[6-(quinolin-2-ylcarbamoyl)-1H-benzimidazol-2-yl]phenyl]-2,2-dimethylpropanoic acid
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C30H28N4O3
 1
1
IC50 = 954 nM
   TI
   LI
   LO
   TS
CP0383424
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-4-methyl-1-phenylpyrazole-3-carboxamide
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C22H24N4O3
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0383469
5-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpyrazol-4-yl]carbonyl}amino)ethyl]pyridine-2-carboxamide
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C19H15ClF3N5O2
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0374309
1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}ethyl)-3-(trifluoromethyl)-1Hpyrazole-4-carboxamide
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C22H20ClF3N4O3
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0461832
2-[4-[6-[(3,4-dimethylphenyl)carbamoyl]-1H-benzimidazol-2-yl]-3,5-dimethylanilino]acetic acid
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C26H26N4O3
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0473494
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-1-pyridin-3-yl-3-(trifluoromethyl)pyrazole-4-carboxamide
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C21H20F3N5O3
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0374311
N-[2-[(3-ethoxybenzoyl)amino]ethyl]-1-phenyl-3-(trifluoromethyl)pyrazole-4-carboxamide
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C22H21F3N4O3
 1
1
IC50 = 5100 nM
   TI
   LI
   LO
   TS
CP0461831
3-[4-[6-[(3,4-dimethylphenyl)carbamoyl]-1H-benzimidazol-2-yl]-3,5-dimethylphenyl]propanoic acid
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C27H27N3O3
 1
1
IC50 = 6500 nM
   TI
   LI
   LO
   TS
CP0401551
N-[2-[(4-ethoxybenzoyl)amino]ethyl]-1-pyridin-4-yl-3-(trifluoromethyl)pyrazole-4-carboxamide
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C21H20F3N5O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0489844
2-[4-[6-[(3,4-dimethylphenyl)carbamoyl]-1H-benzimidazol-2-yl]-3,5-dimethylphenoxy]acetic acid
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C26H25N3O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS