| Compound ID |
Compound Name |
Compound Formula |
|
CP0477176
|
5-[[2-methyl-5-[[3-(trifluoromethyl)phenyl]carbamoyl]anilino]methyl]pyridine-3-carboxamide
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|
C22H19F3N4O2
|
1
|
| 1 |
IC50 = 3.97 nM
|
|
|
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CP0444553
|
4-fluoro-3-[[5-(1-methylpyrazol-3-yl)pyridin-3-yl]methylamino]-N-[3-(trifluoromethoxy)phenyl]benzamide
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|
C24H19F4N5O2
|
1
|
| 1 |
IC50 = 4.67 nM
|
|
|
|
CP0444552
|
3-[(5-methoxypyridin-3-yl)methylamino]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzamide
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|
C22H20F3N3O2
|
1
|
| 1 |
IC50 = 5.89 nM
|
|
|
|
CP0537452
|
4-methyl-3-[[5-(1-methylpyrazol-3-yl)pyridin-3-yl]methylamino]-N-[3-(trifluoromethyl)phenyl]benzamide
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|
C25H22F3N5O
|
1
|
| 1 |
IC50 = 8.53 nM
|
|
|
|
CP0273593
|
(4R)-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C26H23F3N6O
|
1
|
| 1 |
IC50 = 9.4 nM
|
|
|
|
CP0444551
|
4-methyl-3-(pyridin-3-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]benzamide
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|
C21H18F3N3O
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0531963
|
4-methyl-3-[[5-(1H-pyrrol-2-yl)pyridin-3-yl]methylamino]-N-[3-(trifluoromethyl)phenyl]benzamide
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|
C25H21F3N4O
|
1
|
| 1 |
IC50 = 15.2 nM
|
|
|
|
CP0530889
|
(4R)-4-methyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C28H31F3N6O
|
1
|
| 1 |
IC50 = 24.3 nM
|
|
|
|
CP0537181
|
4-methyl-N-[4-methyl-3-(trifluoromethyl)phenyl]-3-[[5-(1H-pyrrol-2-yl)pyridin-3-yl]methylamino]benzamide
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|
C26H23F3N4O
|
1
|
| 1 |
IC50 = 36.4 nM
|
|
|
|
CP0495262
|
(4R)-4-ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C29H33F3N6O
|
1
|
| 1 |
IC50 = 36.4 nM
|
|
|
|
CP0530847
|
D2099
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|
C28H31F3N6O
|
1
|
| 1 |
IC50 = 309 nM
|
|
|
|
CP0529562
|
(4S)-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C26H23F3N6O
|
1
|
| 1 |
IC50 = 326 nM
|
|
|
|
CP0460693
|
D2211
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|
C28H30F3N5O
|
1
|
| 1 |
IC50 = 328 nM
|
|
|
|
CP0495256
|
N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C27H29F3N6O
|
1
|
| 1 |
IC50 = 442 nM
|
|
|
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CP0556860
|
(4R)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C30H35F3N6O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0495261
|
(4S)-4-ethyl-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C29H33F3N6O
|
1
|
| 1 |
IC50 > 2000 nM
|
|
|
|
CP0536445
|
N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-phenyl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C29H31F3N4O
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0556861
|
(4S)-N-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2-pyrimidin-5-yl-3,4-dihydro-1H-isoquinoline-7-carboxamide
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|
C30H35F3N6O
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0382724
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C49H54BF2N7O7
|
1
|
| 1 |
Kd = 674 nM
|
|
|
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CP0382649
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C50H56BF2N7O7
|
1
|
| 1 |
Kd = 888 nM
|
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