Brief Information of the Cell Line and Protein
Cell Line ID: CL000200 , SUP-T1
Synonyms
Sup-T1
SUPT-1
SupT-1
Sup T-1
SUP T-1
SUP T1
Sup T1
SupT1
SUPT1
Tsup-1
VB
Stanford University Pediatric T-cell line 1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1714
Protein ID: PT02059 , C-X-C chemokine receptor type 4
Gene Name CXCR4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P61073
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000200  Protein ID: PT02059
 
Compound ID Compound Name Compound Formula
CP0897003
4,7,10,17-tetraazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-yl{4-[4,7,10,17-tetraazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-ylmethyl]phenyl}methane;octahydrobromide
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C34H51BrN8
 1
1
IC50 = 1 nM
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CP0943584
1,4,8,11-tetraazacyclotetradecanyl[4-(1,4,8,11-tetraazacyclotetradecanylmethyl)phenyl]methane octahydrochloride;dihydrate
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C28H66Cl8N8O2
 1
1
IC50 = 7 nM
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CP0426218
(3R)-4-[[(2R)-6-amino-1-[[(2R)-6-amino-1-[[(2R)-1-[[6-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-4-amino-1-[[(2S)-4-amino-1-[(2S)-2-[[(2S)-5-carbamimidamido-1-[[(2S,3R)-1-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-[[(2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-amino-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
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C122H206N46O33S
 2
1
IC50 = 14 nM
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2
IC50 = 2870 nM
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CP0402847
(3S)-3-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[6-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-amino-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoylamino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]acetyl]amino]-4-[[(2S,3S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
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C123H207N47O30S
 2
1
IC50 = 23 nM
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2
IC50 = 4030 nM
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CP0145769
1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-tetraaza-cyclotetradecane}
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C28H54N8
 4
1
IC50 = 39.777247 nM
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2
IC50 = 44 nM
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3
IC50 = 113.365155 nM
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4
IC50 > 1988.862371 nM
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CP0895050
1,5,8,11-tetraazacyclotetradecanyl[4-(1,5,8,11-tetraazacyclotetradecanylmethyl)phenyl]methane;octahydrobromide;dihydrate
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C28H55BrN8
 1
1
IC50 = 67 nM
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CP0866103
1',1'',1''',1'''',1''''',1'''''',1''''''',1'''''''',1''''''''',1'''''''''',1''''''''''',1''''''''''''-(5,5',5'',5''',5'''',5'''''-(1',1'',1''',1'''',1''''',1''''''-(5,5',5''-(1',1'',1'''-(benzene-1,3,5-triyltris(methylene))tris(4,4'-bipyridine-1,1'-diium-1',1-diyl))tris(methylene)tris(benzene-5,3,1-triyl))hexakis(methylene)hexakis(4,4'-bipyridine-1,1'-diium-1',1-diyl))hexakis(methylene)hexakis(benzene-5,3,1-triyl))dodecakis(methylene)dodecakis(1-ethyl-4,4'-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C324H318F252N42P42
 4
1
IC50 = 101.02114 nM
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2
IC50 = 108.368132 nM
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3
IC50 = 111.123254 nM
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4
IC50 = 180.001304 nM
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CP0037510
(S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine
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C31H32N6
 1
1
IC50 = 120 nM
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CP0852033
1',1'',1''',1'''',1''''',1'''''',1''''''',1'''''''',1''''''''',1'''''''''',1''''''''''',1''''''''''''-(5,5',5'',5''',5'''',5'''''-(1',1'',1''',1'''',1''''',1''''''-(5,5',5''-(1',1'',1'''-(benzene-1,3,5-triyltris(methylene))tris(4',4''-bipyridine-1,1'-diium-1',1'-diyl))tris(methylene)tris(benzene-5,3,1-triyl))hexakis(methylene)hexakis(4'',4'''-bipyridine-1,1'-diium-1'',1'-diyl))hexakis(methylene)hexakis(benzene-5,3,1-triyl))dodecakis(methylene)dodecakis(1-(3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propyl)-4'''''''',4'''''''''-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C396H390F252N66O24P42
 4
1
IC50 = 123.542202 nM
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2
IC50 = 177.741362 nM
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3
IC50 = 191.291152 nM
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4
IC50 = 232.737568 nM
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CP0559510
(3R)-4-[[(2R)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[2-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-6-amino-1-[[(2R)-1-[(2R)-2-[[(2R)-1-[(2R)-2-[[6-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-[[(2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-amino-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
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C151H249N45O36S2
 1
1
IC50 = 147 nM
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CP0562552
(3R)-4-[[(2R)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[2-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-6-amino-1-[[(2R)-1-[(2R)-2-[[(2R)-1-[(2R)-2-[[6-[[(2S)-6-amino-1-[[(2R)-6-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[2-[[(2R)-1-[[(2R)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-[[(2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-amino-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
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C168H265N49O38S2
 1
1
IC50 = 193 nM
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CP0860686
1',1'',1''',1''''-(5,5'-(1',1''-(5-(1'-(3-((1'-(3,5-bis((1'-ethyl-4,4'-bipyridin-1,1'-diium-1-yl)methyl)benzyl)-4,4'-bipyridin-1,1'-diium-1-yl)methyl)-5-((1'-(3-((4-ethyl-1,4'-bipyridin-1,1'-diium-1'-yl)methyl)-5-((1'-ethyl-4,4'-bipyridin-1,1'-diium-1-yl)methyl)benzyl)-4,4'-bipyridin-1,1'-diium-1-yl)methyl)phenyl)-4,4'-bipyridin-1,1'-diium-1-yl)-1,3-phenylene)bis(methylene)bis(4,4'-bipyridine-1,1'-diium-1',1-diyl))bis(methylene)bis(benzene-5,3,1-triyl))tetrakis(methylene)tetrakis(1-ethyl-4,4'-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C198H194F156N26P26
 4
1
IC50 = 202.775641 nM
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2
IC50 = 284.780495 nM
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3
IC50 = 344.42039 nM
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4
IC50 = 445.80821 nM
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CP0852034
1',1'',1''',1'''',1''''',1'''''',1''''''',1''''''''-(5,5',5'',5'''-(1',1'',1''',1''''-(5,5'-(4,4'-bipyridine-1,1'-diium-1,1'-diyl)bis(benzene-5,3,1-triyl))tetrakis(methylene)tetrakis(4',4''-bipyridine-1,1'-diium-1',1'-diyl))tetrakis(methylene)tetrakis(benzene-5,3,1-triyl))octakis(methylene)octakis(1-(3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propyl)-4',4''-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C246H242F156N42O16P26
 4
1
IC50 = 207.37513 nM
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2
IC50 = 209.935317 nM
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3
IC50 = 235.537185 nM
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4
IC50 = 326.423816 nM
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CP0866102
1',1'',1''',1'''',1''''',1''''''-(5,5',5''-(1',1'',1'''-(benzene-1,3,5-triyltris(methylene))tris(4,4'-bipyridine-1,1'-diium-1',1-diyl))tris(methylene)tris(benzene-5,3,1-triyl))hexakis(methylene)hexakis(1-(3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propyl)-4,4'-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C174H174F108N30O12P18
 4
1
IC50 = 231.463762 nM
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2
IC50 = 351.752017 nM
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3
IC50 = 402.783397 nM
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4
IC50 = 515.781454 nM
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CP0504536
N-(1H-benzimidazol-2-ylmethyl)-N-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
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C31H32N6
 1
1
IC50 = 250 nM
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CP0860688
1',1'',1''',1'''',1''''',1''''''-(5,5',5''-(1',1'',1'''-(benzene-1,3,5-triyltris(methylene))tris(4,4'-bipyridine-1,1'-diium-1',1-diyl))tris(methylene)tris(benzene-5,3,1-triyl))hexakis(methylene)hexakis(1-ethyl-4,4'-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C138H138F108N18P18
 4
1
IC50 = 259.764795 nM
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2
IC50 = 309.141574 nM
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3
IC50 = 377.839702 nM
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4
IC50 = 463.712361 nM
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CP0853531
1',1'',1''',1''''-(5,5'-(4,4'-bipyridine-1,1'-diium-1,1'-diyl)bis(benzene-5,3,1-triyl))tetrakis(methylene)tetrakis(1-ethyl-4,4'-bipyridine-1,1'-diium)hexafluorophosphate
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C74H74F60N10P10
 4
1
IC50 = 544.436176 nM
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2
IC50 = 767.694176 nM
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3
IC50 = 3364.537229 nM
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4
IC50 = 5800.791195 nM
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CP0383950
(3R)-3-[[(2R)-1-[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-amino-4-methylpentanoyl]amino]acetyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-4-[[(2R)-1,6-diamino-1-oxohexan-2-yl]amino]-4-oxobutanoic acid
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C52H80N18O13
 1
1
IC50 = 615 nM
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CP0857948
1',1'',1''',1''''-(5,5'-(4,4'-bipyridine-1,1'-diium-1,1'-diyl)bis(benzene-5,3,1-triyl))tetrakis(methylene)tetrakis(1-(3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propyl)-4,4'-bipyridine-1,1'-diium)hexafluorophosphate (V)
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C98H98F60N18O8P10
 4
1
IC50 = 660.097888 nM
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2
IC50 = 724.497682 nM
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3
IC50 = 3078.310149 nM
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4
IC50 = 3403.529109 nM
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CP0957174
3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-6-yl{4-[3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-6-ylmethyl]phenyl}methane;octahydrobromide
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C30H43BrN8
 1
1
IC50 = 4363 nM
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CP0881765
15-chloro-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-yl{4-[15-chloro-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-ylmethyl]phenyl}methane;hexahydrobromide;acetic acid
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C36H53BrCl2N8O2
 1
1
IC50 = 5737 nM
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CP0402848
(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(6-aminohexanoylamino)hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoic acid
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C58H105N23O18S
 1
1
IC50 = 7418 nM
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CP0418003
(R)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine
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C31H32N6
 1
1
IC50 = 29200 nM
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CP0861180
7-{4-[15-hydroxy-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-ylmethyl]benzyl}-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-15-ol;octahydrobromide
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C34H51BrN8O2
 1
1
IC50 > 35000 nM
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CP0879082
5,8-dioxa-1,12-diazacyclotetradecanyl[4-(5,8-dioxa-1,12-diazacyclotetradecanylmethyl)phenyl]methane;tetra hydrochloride;2.5 hydrate
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C28H51ClN4O4
 1
1
IC50 > 35000 nM
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CP0879270
5,8-dithia-1,12-diazacyclotetradecanyl[4-(5,8-dithia-1,12-diazacyclotetradecanylmethyl)phenyl]methane;tetra hydrochloride
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C28H51ClN4S4
 1
1
IC50 > 35000 nM
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CP0890584
3,7,11,15,17-pentaazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-yl{4-[3,7,11,15,17-pentaazabicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-7-ylmethyl]phenyl}methane;heptahydrobromide;dacetic acid
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C34H53BrN10O2
 1
1
IC50 > 35000 nM
   TI
   LI
   LO
   TS
CP0951801
1,5,11-triazacyclotetradecanyl[4-(1,5,11-triazacyclotetradecanylmethyl)phenyl]methane ;hexahydrobromide;5hydrate
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C30H57BrN6
 1
1
IC50 > 35000 nM
   TI
   LI
   LO
   TS
CP0384173
(3S)-3-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(6-aminohexanoylamino)hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]acetyl]amino]-4-[[(2S,3S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-amino-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
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C59H106N24O15S
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS