Brief Information of the Cell Line and Protein
Cell Line ID: CL000920 , MCF-7/DX1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0031
Protein ID: PT01546 , ATP-dependent translocase ABCB1
Gene Name ABCB1
Organism Homo sapiens, Human
Protein Classification Transporter
Uniprot ID P08183
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000920  Protein ID: PT01546
 
Compound ID Compound Name Compound Formula
CP0482088
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 7-[1-[7-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-7-oxoheptyl]triazol-4-yl]heptanoate
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C56H71N7O6
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0460779
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 7-[1-[5-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-5-oxopentyl]triazol-4-yl]heptanoate
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C54H67N7O6
 1
1
IC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0482087
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 7-[4-[5-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-5-oxopentyl]triazol-1-yl]heptanoate
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C54H67N7O6
 1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0378072
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 7-[4-[3-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-3-oxopropyl]triazol-1-yl]heptanoate
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C52H63N7O6
 1
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0566450
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 9-[1-[9-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-9-oxononyl]triazol-4-yl]nonanoate
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C60H79N7O6
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0549062
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 5-[1-[5-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-5-oxopentyl]triazol-4-yl]pentanoate
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C52H63N7O6
 1
1
IC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0462710
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 3-[1-[3-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-3-oxopropyl]triazol-4-yl]propanoate
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C48H55N7O6
 1
1
IC50 = 6100 nM
   TI
   LI
   LO
   TS
CP0460778
[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] 5-[4-[3-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-3-oxopropyl]triazol-1-yl]pentanoate
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C50H59N7O6
 1
1
IC50 = 6200 nM
   TI
   LI
   LO
   TS