Brief Information of the Cell Line and Protein
Cell Line ID: CL000035 , NIH 3T3
Synonyms
NIH/3T3
NIH-3T3
NIH3T3
3T3
3T3NIH
3T3-Swiss
Swiss-3T3
Swiss/3T3
Swiss 3T3
Swiss3T3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Protein ID: PT01480 , 5-hydroxytryptamine receptor 2C
Gene Name HTR2C
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P08909
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000035  Protein ID: PT01480
 
Compound ID Compound Name Compound Formula
CP0057346
3-(2-aminopropyl)-1H-indol-5-ol
   Show/Hide
C11H14N2O
 1
1
EC50 = 1.8 nM
   TI
   LI
   LO
   TS
CP0001238
14C-5-hydroxy tryptamine creatinine disulfate
   Show/Hide
C10H12N2O
 1
1
EC50 = 2.8 nM
   TI
   LI
   LO
   TS
CP0099665
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine
   Show/Hide
C12H16N2O
 1
1
EC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0044585
1-((S)-2-aminopropyl)-1H-indazol-6-ol
   Show/Hide
C10H13N3O
 1
1
EC50 = 3.7 nM
   TI
   LI
   LO
   TS
CP0394695
phenyl 2-[[8-[(2R)-2-aminopropyl]-2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran-4-yl]methoxy]acetate
   Show/Hide
C22H25NO5
 1
1
EC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0431209
1-(2-aminoethyl)-1H-indazol-6-ol
   Show/Hide
C9H11N3O
 1
1
EC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0422213
1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol
   Show/Hide
C10H12ClN3O
 1
1
EC50 = 4.9 nM
   TI
   LI
   LO
   TS
CP0372474
1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol
   Show/Hide
C10H12FN3O
 1
1
EC50 = 5.5 nM
   TI
   LI
   LO
   TS
CP0386221
(2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine
   Show/Hide
C11H15N3O
 1
1
EC50 = 6.7 nM
   TI
   LI
   LO
   TS
CP0431212
1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol
   Show/Hide
C11H15N3O
 1
1
EC50 = 7.3 nM
   TI
   LI
   LO
   TS
CP0373329
(R)-2-[8-(2-methoxy-ethoxymethyl)-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']difuran-4-yl]-1-methyl-ethylamine
   Show/Hide
C17H25NO4
 1
1
EC50 = 8.6 nM
   TI
   LI
   LO
   TS
CP0373330
(R)-2-(8-methoxymethyl-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']difuran-4-yl)-1-methyl-ethylamine
   Show/Hide
C15H21NO3
 1
1
EC50 = 12.6 nM
   TI
   LI
   LO
   TS
CP0057042
(R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
   Show/Hide
C11H16INO2
 1
1
EC50 = 30.2 nM
   TI
   LI
   LO
   TS
CP0442976
(1R,2R)-2-amino-1-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']difuran-4-yl)-propan-1-ol
   Show/Hide
C13H16BrNO3
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0071154
2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine
   Show/Hide
C13H18N2O
 1
1
EC50 = 77.8 nM
   TI
   LI
   LO
   TS
CP0394899
(R)-1-methyl-2-[8-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-benzo[1,2-b;4,5-b']difuran-4-yl]-ethylamine
   Show/Hide
C17H17N3O3
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0372472
1-((R)-2-aminopropyl)-1H-indazol-6-ol
   Show/Hide
C10H13N3O
 1
1
EC50 = 87.3 nM
   TI
   LI
   LO
   TS
CP0394693
(R)-1-methyl-2-[8-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']difuran-4-yl]-ethylamine
   Show/Hide
C17H21N3O3
 1
1
EC50 = 689 nM
   TI
   LI
   LO
   TS
CP0031743
1H-imidazo[4,5-c]pyridine derivative
   Show/Hide
C18H26N4O2S
 1
1
Ki = 0.37 nM
   TI
   LI
   LO
   TS
CP0046703
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
   Show/Hide
C24H26ClFN4O
 1
1
Ki = 0.51 nM
   TI
   LI
   LO
   TS
CP0005956
1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-piperazine
   Show/Hide
C19H19ClN2O
 1
1
Ki = 3 nM
   TI
   LI
   LO
   TS
CP0003324
1-(8-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine
   Show/Hide
C20H21ClN2
 1
1
Ki = 6 nM
   TI
   LI
   LO
   TS
CP0008953
1-(2-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-piperazine
   Show/Hide
C19H19ClN2O
 1
1
Ki = 6 nM
   TI
   LI
   LO
   TS
CP0010829
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine
   Show/Hide
C19H20N2O
 1
1
Ki = 6 nM
   TI
   LI
   LO
   TS
CP0002406
1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine
   Show/Hide
C20H21ClN2
 1
1
Ki = 7 nM
   TI
   LI
   LO
   TS
CP0874541
4-Dibenzo[b,f]oxepin-10-yl-1-methyl-piperidine hydrochloride
   Show/Hide
C20H22ClNO
 1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
CP0885801
4-Dibenzo[b,f]oxepin-10-yl-1-ethyl-1,2,3,6-tetrahydro-pyridine hydrochloride
   Show/Hide
C21H22ClNO
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0005197
1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten-10-yl)-piperazine
   Show/Hide
C21H22N2
 1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
CP0005613
8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine
   Show/Hide
C18H18ClN3O
 1
1
Ki = 19 nM
   TI
   LI
   LO
   TS
CP0391139
4-Dibenzo[b,f]oxepin-10-yl-1-methyl-1,2,3,6-tetrahydro-pyridine
   Show/Hide
C20H19NO
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0183655
1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10-yl)-piperazine
   Show/Hide
C21H24N2
 1
1
Ki = 36 nM
   TI
   LI
   LO
   TS
CP0406243
1-(2-{4-[5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H32FN7O
 1
1
Ki = 37 nM
   TI
   LI
   LO
   TS
CP0448256
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-pyrazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H31FN6O
 1
1
Ki = 45 nM
   TI
   LI
   LO
   TS
CP0490676
1-(2-{4-[1-(4-Fluoro-phenyl)-5-pyridin-3-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C29H30FN5O
 1
1
Ki = 50 nM
   TI
   LI
   LO
   TS
CP0845312
1-Allyl-4-dibenzo[b,f]oxepin-10-yl-1,2,3,6-tetrahydro-pyridine hydrochloride
   Show/Hide
C22H22ClNO
 1
1
Ki = 51 nM
   TI
   LI
   LO
   TS
CP0384143
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
 1
1
Ki = 73 nM
   TI
   LI
   LO
   TS
CP0004912
1-[5-Eth-(Z)-ylidene-5H-dibenzo[a,d]cyclohepten-10-yl]-4-methyl-piperazine
   Show/Hide
C22H24N2
 1
1
Ki = 110 nM
   TI
   LI
   LO
   TS
CP0453890
1-(2-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-5-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H29FN6O
 1
1
Ki = 120 nM
   TI
   LI
   LO
   TS
CP0492027
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-imidazol-2-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H31FN6O
 1
1
Ki = 130 nM
   TI
   LI
   LO
   TS
CP0376628
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(3-methyl-3H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
 1
1
Ki = 140 nM
   TI
   LI
   LO
   TS
CP0392710
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C26H28FN7O
 1
1
Ki = 150 nM
   TI
   LI
   LO
   TS
CP0404715
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C26H29FN8O
 1
1
Ki = 180 nM
   TI
   LI
   LO
   TS
CP0459887
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
 1
1
Ki = 190 nM
   TI
   LI
   LO
   TS
CP0228798
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C26H29FN8O
 1
1
Ki = 330 nM
   TI
   LI
   LO
   TS
CP0277576
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-pyrazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H31FN6O
 1
1
Ki = 330 nM
   TI
   LI
   LO
   TS
CP0000272
1-(2-Chloro-5-isopropylidene-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine
   Show/Hide
C23H25ClN2
 1
1
Ki = 370 nM
   TI
   LI
   LO
   TS
CP0011263
1-(5-Isopropylidene-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine
   Show/Hide
C23H26N2
 1
1
Ki = 390 nM
   TI
   LI
   LO
   TS
CP0382930
1-(2-{4-[5-(1-Ethyl-1H-[1,2,3]triazol-4-yl)-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H32FN7O
 1
1
Ki = 500 nM
   TI
   LI
   LO
   TS
CP0502318
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H31FN6O
 1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0429995
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(4-methyl-4H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
 1
1
Ki = 1100 nM
   TI
   LI
   LO
   TS
CP0382893
1-(2-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C28H29FN6O
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0126860
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
 1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
CP0072419
(SNAP-8719)[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-octahydro-quinoxalin-1-yl]-furan-2-yl-methanone
   Show/Hide
C22H28F3N3O2
 1
1
Ki = 2600 nM
   TI
   LI
   LO
   TS
CP0151333
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
   Show/Hide
C27H30FN7O
 1
1
Ki = 2900 nM
   TI
   LI
   LO
   TS
CP0040814
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
   Show/Hide
C19H21N5O4
 1
1
Ki > 4200 nM
   TI
   LI
   LO
   TS