Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01460 , Kappa-type opioid receptor
Gene Name OPRK1
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P34975
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01460
 
Compound ID Compound Name Compound Formula
CP0452579
3-(2-(3-tert-Butylphenyl)-5-((dimethylamino)methyl)-2H-1,2,4-triazol-3-yl)phenol
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C21H26N4O
 1
1
IC50 = 46.3 nM
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CP0390376
3-(5-(3-tert-Butylphenyl)-3-((dimethylamino)methyl)-1H-1,2,4-triazol-1-yl)phenol
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C21H26N4O
 1
1
IC50 = 341 nM
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CP0390387
3-(3-((Dimethylamino)methyl)-5-(2,4-dimethylphenyl)-1H-1,2,4-triazol-1-yl)phenol
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C19H22N4O
 1
1
IC50 = 351 nM
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CP0373889
3-(2-(4-tert-Butylphenyl)-5-((dimethylamino)methyl)-2H-1,2,4-triazol-3-yl)phenol
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C21H26N4O
 1
1
IC50 = 760 nM
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CP0041255
(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide
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C28H39N3O2
 1
1
IC50 = 3601 nM
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CP0038385
3-(5-(4-tert-butylphenyl)-3-((dimethylamino)methyl)-1H-1,2,4-triazol-1-yl)phenol
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C21H26N4O
 1
1
IC50 = 3851 nM
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CP0373269
(5-(2,4-Dimethylphenyl)-1-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
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C20H24N4O
 1
1
IC50 > 10000 nM
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CP0373884
(5-(4-tert-Butylphenyl)-1-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
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C22H28N4O
 1
1
IC50 > 10000 nM
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CP0417784
(1-(4-tert-Butylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
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C22H28N4O
 1
1
IC50 > 10000 nM
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CP0452580
(1-(3-tert-Butylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
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C22H28N4O
 1
1
IC50 > 10000 nM
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CP0510367
(5-(3-tert-Butylphenyl)-1-(3-methoxyphenyl)-1H-1,2,4-triazol-3-yl)-N,N-dimethylmethanamine
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C22H28N4O
 1
1
IC50 > 10000 nM
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CP0035617
N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide
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C22H32N2O2
 1
1
Kd = 1 nM
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CP0054764
2-[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]guanidine
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C27H29N5O3
 3
1
Ki = 0.03 nM
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2
Ki = 0.18 nM
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3
Ki = 3.9 nM
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CP0041449
C18130
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C40H43N3O6
 4
1
Ki = 0.07 nM
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2
Ki = 0.24 nM
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3
Ki = 0.244 nM
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4
Ki = 1.39 nM
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CP0430310
5'-Amidinomethyl-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C28H30N4O3
 1
1
Ki = 0.214 nM
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CP0409091
5'-N-Biguanidino-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C28H31N7O3
 1
1
Ki = 0.226 nM
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CP0848535
5'-(Trimethylammonium)methyl-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan Iodide
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C30H36IN3O3
 1
1
Ki = 0.354 nM
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CP0377768
2-[2-[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]ethyl]guanidine
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C29H33N5O3
 1
1
Ki = 0.507 nM
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CP0405336
5'-Amidino-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C27H28N4O3
 1
1
Ki = 0.529 nM
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CP0381067
2-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]methyl]guanidine
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C28H31N5O3
 1
1
Ki = 0.745 nM
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CP0505602
5'-(Dimethylamino)methyl-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C29H33N3O3
 1
1
Ki = 0.823 nM
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CP0050068
(1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
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C26H26N2O3
 3
1
Ki = 1.23 nM
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2
Ki = 25.5 nM
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3
Ki = 42 nM
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CP0048724
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
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C20H23NO4
 3
1
Ki = 1.8 nM
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2
Ki = 4.2 nM
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3
Ki = 12.7 nM
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CP0402523
6,7-Dihydro-4,5alpha-epoxy-5'-guanidinyl-17-methyl-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C24H25N5O3
 1
1
Ki = 2.83 nM
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CP0036843
(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(furan-3-yl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester
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C23H28O8
 1
1
Ki = 4 nM
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CP0182209
5'-[N-(N'-Cyano)guanidinyl]-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan
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C28H28N6O3
 1
1
Ki = 4.46 nM
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CP0505690
(3S,4aR,4bS,6S,8R,8aR)-6-Acetoxy-3-furan-3-yl-4a,8a-dimethyl-5-oxo-4,4a,4b,5,6,7,8,8a,9,10-decahydro-3H-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H28O7
 1
1
Ki = 6 nM
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CP0510348
(3S,4aS,4bR,6S,8R,8aR,10aR)-6-Acetoxy-3-furan-3-yl-4a,8a-dimethyl-5-oxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H30O7
 1
1
Ki = 6 nM
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CP0169508
(3S,4aR,4bS,6R,8R,8aR,10aR)-6-Acetoxy-3-furan-3-yl-4a,8a-dimethyl-1-oxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H30O7
 1
1
Ki = 18 nM
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CP0395488
(3S,4aR,4bS,6S,8R,8aR,10aR)-6-Formyloxy-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C22H26O8
 1
1
Ki = 18 nM
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CP0676197
N-(2-(Benzyl(tert-butyl)amino)ethyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
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C30H37N3O3S
 1
1
Ki = 37 nM
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CP0058181
4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(phenylmethyl)-propan-2-yl-amino]ethyl]benzamide
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C27H33N3O3S
 1
1
Ki = 50 nM
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CP0717802
N-(2-((4-Chlorobenzyl)(tert-butyl)amino)ethyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
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C30H36ClN3O3S
 1
1
Ki = 53 nM
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CP0096567
7-(2'-spiroindanyl)oxymorphone
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C25H25NO4
 3
1
Ki = 55 nM
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2
Ki = 292 nM
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3
Ki = 488 nM
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CP0494837
(3S,4aS,4bR,6S,8R,8aR,10aR)-6-Acetoxy-3-furan-3-yl-1-hydroxy-4a,8a-dimethyl-5-oxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H30O8
 1
1
Ki = 59 nM
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CP0667615
N-(2-((4-Bromobenzyl)(isopropyl)amino)ethyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
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C29H34BrN3O3S
 1
1
Ki = 73 nM
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CP0048256
10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
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C17H19NO4
 3
1
Ki = 95 nM
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2
Ki = 208 nM
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3
Ki = 435 nM
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CP0378873
(2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,10b-dimethyl-4,10-dioxo-2-((R)-tetrahydrofuran-3-yl)-dodecahydro-1H-benzo[f]isochromene-7-carboxylate
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C23H32O8
 1
1
Ki = 156 nM
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CP0391557
(3S,4aR,4bS,6S,8R,8aR,10aS)-6-Acetoxy-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H28O8
 1
1
Ki = 163 nM
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CP0378809
(2S,4aR,6aS,7R,9S,10aS,10bR)-2-(furan-3-yl)-7-(hydroxymethyl)-6a,10b-dimethyl-4,10-dioxo-dodecahydro-1H-benzo[f]isochromen-9-yl acetate
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C22H28O7
 1
1
Ki = 347 nM
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CP0515409
(3S,4aR,4bR,5R,6S,8aR,10aR)-5,6-Diacetoxy-3-furan-3-yl-4a,8a-dimethyl-1-oxo-3,4,4a,4b,5,6,8a,9,10,10a-decahydro-1H-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C25H30O9
 1
1
Ki = 1022 nM
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CP0860586
(3S,4aR,4bS,5R,6S,8R,8aR,10aR)-5-Acetoxy-3-furan-3-yl-6-hydroxy-4a,8a-dimethyl-1-oxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H30O8
 1
1
Ki = 1125 nM
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CP0384142
(S,E)-(2,3,5,6,7,9a-hexahydro-1H-pyrrolo[1,2-a]azepin-9-yl)(2-hydroxy-6-methylphenyl)methanone
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C17H21NO2
 1
1
Ki = 4000 nM
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CP0050256
(3S,4aR,4bS,5R,6S,8R,8aR,10aR)-5,6-Diacetoxy-3-furan-3-yl-4a,8a-dimethyl-1-oxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C25H32O9
 1
1
Ki > 10000 nM
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CP0496079
(3S,4aR,4bR,5R,6S,8aR,10aR)-5-Acetoxy-3-furan-3-yl-6-hydroxy-4a,8a-dimethyl-1-oxo-3,4,4a,4b,5,6,8a,9,10,10a-decahydro-1H-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H28O8
 1
1
Ki > 10000 nM
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CP0510347
(3S,4aR,4bR,5R,6S,8aR,10aR)-6-Acetoxy-3-furan-3-yl-5-hydroxy-4a,8a-dimethyl-1-oxo-3,4,4a,4b,5,6,8a,9,10,10a-decahydro-1H-2-oxa-phenanthrene-8-carboxylic acid methyl ester
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C23H28O8
 1
1
Ki > 10000 nM
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CP0134916
1-{3-[3-(tert-butyl) phenyl]-5-N,N-dimethylaminomethyl-(1,2,4-triazol-4-yl) }-3-phenol
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C21H26N4O
 1
1
Ki > 10000 nM
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CP0221707
1-{3-[4-(tert-butyl) phenyl]-5-N,N-dimethylaminomethyl-(1,2,4-triazol-4-yl)}-3-phenol
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C21H26N4O
 1
1
Ki > 10000 nM
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CP0850124
elaeocarpenine
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C16H19NO2
 1
1
Ki = 12000 nM
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CP0501690
(S)-(1,2,3,5,6,8a-hexahydroindolizin-8-yl)(2-methoxy-6-methylphenyl)methanone
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C17H21NO2
 1
1
Ki = 20000 nM
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CP0390056
(S)-(1,2,3,5,6,8a-hexahydroindolizin-8-yl)(2-hydroxy-6-methylphenyl)methanone
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C16H19NO2
 1
1
Ki = 24000 nM
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CP0498934
(S)-(2-hydroxy-6-methylphenyl)(2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)methanone
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C15H17NO2
 1
1
Ki = 35000 nM
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CP0384140
(S)-(1,2,3,5,6,8a-hexahydroindolizin-8-yl)(2-hydroxyphenyl)methanone
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C15H17NO2
 1
1
Ki = 83000 nM
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