Brief Information of the Cell Line and Protein
Cell Line ID: CL000031 , MDCK
 Cell Line Info 
Synonyms
MDCK (NBL-2)
MDCK(NBL-2)
NBL-2
Madin-Darby Canine Kidney
Madin Darby Canine Kidney
Category Spontaneously immortalized cell line
Organism
Canis lupus familiaris (Dog)
Cellosaurus ID
CVCL_0422
Protein ID: PT01247 , Metabotropic glutamate receptor 5
 Protein Info 
Gene Name GRM5
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P31424
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000031
 Cell Line Info 
 Protein ID: PT01247
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0109091
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-7-methyl-5-(4-methylphenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19ClN4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0158189
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-5-(6-fluoropyridin-2-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C18H15ClFN5O2
  1
1
EC50 > 10000 nM
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CP0158190
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-5-(6-fluoropyridin-3-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C18H15ClFN5O2
  1
1
EC50 > 10000 nM
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CP0199063
 Compound Info 
(7R)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-5-pyridin-3-yl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C18H16FN5O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0199153
 Compound Info 
(7R)-5-(4-fluorophenyl)-7-methyl-2-[(3-methylphenoxy)methyl]-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C21H20FN3O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0199590
 Compound Info 
(7R)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-5-(3-methylphenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19FN4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0263025
 Compound Info 
(7R)-5-(2-fluorophenyl)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C19H16F2N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0263032
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-5-(2-methoxyphenyl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19ClN4O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0313224
 Compound Info 
(7R)-5-(4-fluorophenyl)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C19H16F2N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0318736
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-5-(5-fluoropyridin-2-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C18H15ClFN5O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0326400
 Compound Info 
(7R)-5-(4-fluorophenyl)-2-[(4-methoxypyridin-2-yl)oxymethyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19FN4O3
  1
1
EC50 > 10000 nM
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CP0326402
 Compound Info 
(7R)-5-(4-fluorophenyl)-2-[(2-methoxyphenoxy)methyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C21H20FN3O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0326404
 Compound Info 
(7R)-2-[(3-chlorophenoxy)methyl]-5-(4-fluorophenyl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H17ClFN3O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0326405
 Compound Info 
(7R)-5-(2,5-difluorophenyl)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C19H15F3N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0326406
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-5-(3,5-difluorophenyl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C19H15ClF2N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0345922
 Compound Info 
(7R)-5-(4-fluorophenyl)-2-[(6-methoxypyridin-2-yl)oxymethyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19FN4O3
  1
1
EC50 > 10000 nM
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CP0345928
 Compound Info 
(7R)-2-[(5-fluoropyridin-2-yl)oxymethyl]-5-(3-methoxyphenyl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19FN4O3
  1
1
EC50 > 10000 nM
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CP0363217
 Compound Info 
(7R)-5-(4-fluorophenyl)-7-methyl-2-[[4-(trifluoromethyl)pyridin-2-yl]oxymethyl]-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H16F4N4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0363218
 Compound Info 
(7R)-5-(4-fluorophenyl)-7-methyl-2-[(4-methylpyridin-2-yl)oxymethyl]-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19FN4O2
  1
1
EC50 > 10000 nM
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CP0363220
 Compound Info 
3-[(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-7-methyl-4-oxo-6,7-dihydropyrazolo[1,5-a]pyrazin-5-yl]benzonitrile
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C20H16ClN5O2
  1
1
EC50 > 10000 nM
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CP0370736
 Compound Info 
(7R)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-5-(4-methylphenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C20H19FN4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0370740
 Compound Info 
(7R)-2-[(5-chloropyridin-2-yl)oxymethyl]-5-(3-fluoropyridin-2-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
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C18H15ClFN5O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0444547
 Compound Info 
(7R)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-5-(2-methylphenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
   Show/Hide
C20H19FN4O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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