Brief Information of the Cell Line and Protein
Cell Line ID: CL000407 , CEM-SS
Synonyms
CEM-ss
CEM SS
CEM_SS
CEMss
CEM-Syncitial Sensitive
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_J318
Protein ID: PT00005 , Reverse transcriptase/RNaseH
Gene Name POL
Organism Human immunodeficiency virus 1
Protein Classification Enzyme
Uniprot ID Q72547
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000407  Protein ID: PT00005
 
Compound ID Compound Name Compound Formula
CP0041607
(AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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C10H13N5O4
 2
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0043259
3-Amino-4-(3,5-dimethylbenzyl)-5-ethyl-6-methylpyridin-2(1H)-one
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C17H22N2O
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0422939
methyl 5-[6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-2,4-dioxopyrimidin-1-yl]pentanoate
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C20H26N2O4S
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0121940
4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
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C9H13N3O3
 1
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
CP0471790
5-[6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-2,4-dioxopyrimidin-1-yl]-N-[12-[[1-[5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]amino]dodecyl]pentanamide
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C40H60N6O6S
 1
1
EC50 = 430 nM
   TI
   LI
   LO
   TS
CP0460065
2-amino-N-[2-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-2-oxoethyl]acetamide
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C21H28N4O3
 1
1
EC50 = 720 nM
   TI
   LI
   LO
   TS
CP0428945
ethyl 3-[3-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2,6-dioxopyrimidin-1-yl]propanoate
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C15H21N5O6
 1
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
CP0424419
N-[10-[3-[1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanoylamino]decyl]-5-[6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-2,4-dioxopyrimidin-1-yl]pentanamide
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C41H59N9O8S
 1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0380938
N-[10-[3-[3-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2,6-dioxopyrimidin-1-yl]propanoylamino]decyl]-5-[6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-2,4-dioxopyrimidin-1-yl]pentanamide
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C42H61N9O8S
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0464080
tert-butyl N-[2-[[2-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
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C26H36N4O5
 1
1
EC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0393339
N-[4-[3-[1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanoylamino]butyl]-5-[6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-2,4-dioxopyrimidin-1-yl]pentanamide
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C35H47N9O8S
 1
1
EC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0497129
5-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-5-oxopentanoic acid
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C22H28N2O4
 1
1
EC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0419229
4-(12-aminododecylamino)-1-[5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
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C21H38N4O3
 1
1
EC50 = 7800 nM
   TI
   LI
   LO
   TS
CP0393583
tert-butyl N-[10-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-10-oxodecyl]carbamate
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C32H49N3O4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0422938
10-[3-[[3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]propanoylamino]-N-[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]decanamide
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C40H56N8O7
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0493892
methyl 10-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-10-oxodecanoate
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C28H40N2O4
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0375001
N-(10-aminodecyl)-3-[1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanamide
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C22H37N7O5
 1
1
EC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0461014
methyl 5-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-5-oxopentanoate
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C23H30N2O4
 1
1
EC50 = 24000 nM
   TI
   LI
   LO
   TS
CP0507456
N-[4-[3-[[3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]propanoylamino]butyl]-N'-[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]pentanediamide
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C39H53N9O8
 1
1
EC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0405196
N-[4-[3-[[3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]propanoylamino]butyl]-N'-[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]decanediamide
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C44H63N9O8
 1
1
EC50 = 33000 nM
   TI
   LI
   LO
   TS
CP0487063
N-(10-aminodecyl)-3-[3-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2,6-dioxopyrimidin-1-yl]propanamide
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C23H39N7O5
 1
1
EC50 = 42000 nM
   TI
   LI
   LO
   TS
CP0408439
10-amino-N-[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]decanamide
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C27H41N3O2
 1
1
EC50 = 58000 nM
   TI
   LI
   LO
   TS
CP0529579
10-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-10-oxodecanoic acid
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C27H38N2O4
 1
1
EC50 = 70000 nM
   TI
   LI
   LO
   TS
CP0379332
4-[3-[[3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]propanoylamino]-N-[2-[[2-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-6-methyl-2-oxo-1H-pyridin-3-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]butanamide
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C38H50N10O9
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0380416
methyl 4-[3-[1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanoylamino]butanoate
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C17H24N6O7
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0493867
N-(4-aminobutyl)-3-[1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanamide
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C16H25N7O5
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0507450
methyl 3-[1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanoate
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C13H17N5O6
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0392564
5,6-Dichloro-1-(4-chloro-benzyl)-1H-benzoimidazol-2-ylamine
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C14H10Cl3N3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0539509
5,6-Dichloro-1-(4-trifluoromethyl-benzyl)-1H-benzoimidazol-2-ylamine
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C15H10Cl2F3N3
 1
1
IC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0448221
2-Bromo-5,6-dichloro-1-(3-nitro-benzyl)-1H-benzoimidazole
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C14H8BrCl2N3O2
 1
1
IC50 > 32000 nM
   TI
   LI
   LO
   TS
CP0459217
2-Bromo-5,6-dichloro-1-(3-methyl-benzyl)-1H-benzoimidazole
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C15H11BrCl2N2
 1
1
IC50 = 66000 nM
   TI
   LI
   LO
   TS
CP0374127
1-(3,5-Bis-trifluoromethyl-benzyl)-2-bromo-5,6-dichloro-1H-benzoimidazole
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C16H7BrCl2F6N2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0383183
2-Bromo-5,6-dichloro-1-(3,4-dichloro-benzyl)-1H-benzoimidazole
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C14H7BrCl4N2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0459221
2,5,6-Trichloro-1-(4-nitro-benzyl)-1H-benzoimidazole
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C14H8Cl3N3O2
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0511281
2-Bromo-5,6-dichloro-1-(4-methoxy-benzyl)-1H-benzoimidazole
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C15H11BrCl2N2O
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS