General Information of the Compound
Compound ID
CP0964191
Compound Name
4-amino-5-[3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methylamino]propyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
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Structure
Formula
C22H31N9O7
Molecular Weight
533.546
Canonical SMILES
Nc1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1CCCNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O
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InChI
InChI=1S/C22H31N9O7/c23-18-10(6-30(22(36)29-18)14-4-11(33)13(7-32)37-14)2-1-3-25-5-12-16(34)17(35)21(38-12)31-9-28-15-19(24)26-8-27-20(15)31/h6,8-9,11-14,16-17,21,25,32-35H,1-5,7H2,(H2,23,29,36)(H2,24,26,27)/t11-,12+,13+,14+,16+,17+,21+/m0/s1
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InChIKey
ACVXXVOFCAHBAT-HJKWLTBHSA-N
Physicochemical Property
logP
-2.9703
Rotatable Bonds
9
Heavy Atom Count
38
Polar Areas
241.94
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
16
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168290732
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02598, DNA (cytosine-5)-methyltransferase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 10300 nM
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