General Information of the Compound
Compound ID
CP0963828
Compound Name
N,N-diethyl-5-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)phenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide
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Structure
Formula
C26H26N4OS
Molecular Weight
442.588
Canonical SMILES
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCCC5)cc4C3)c2)nc2ccccc21
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InChI
InChI=1S/C26H26N4OS/c1-28-22-10-3-2-9-21(22)27-25(28)18-7-6-8-20(15-18)30-14-11-23-19(17-30)16-24(32-23)26(31)29-12-4-5-13-29/h2-3,6-10,15-16H,4-5,11-14,17H2,1H3
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InChIKey
JJXURMGKHDVKHJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.1005
Rotatable Bonds
3
Heavy Atom Count
32
Polar Areas
41.37
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127049057
ChEMBL ID
CHEMBL3819236
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 352 nM
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