General Information of the Compound
Compound ID
CP0963368
Compound Name
4-(1-(2-(piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)isothiazole
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Structure
Formula
C15H18N6S
Molecular Weight
314.418
Canonical SMILES
c1nc(-c2cnsc2)c2cnn(CCN3CCCCC3)c2n1
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InChI
InChI=1S/C15H18N6S/c1-2-4-20(5-3-1)6-7-21-15-13(9-18-21)14(16-11-17-15)12-8-19-22-10-12/h8-11H,1-7H2
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InChIKey
OBOSSIOQXBMJCW-UHFFFAOYSA-N
Physicochemical Property
logP
2.4357
Rotatable Bonds
4
Heavy Atom Count
22
Polar Areas
59.73
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 74767364
ChEMBL ID
CHEMBL4293066
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01509, Sigma non-opioid intracellular receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 475 nM
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