General Information of the Compound
Compound ID
CP0958970
Compound Name
4-(3-((2-chloro-4-(trifluoromethyl)phenoxy)methyl)phenyl)azetidin-2-one
    Show/Hide
Structure
Formula
C17H13ClF3NO2
Molecular Weight
355.743
Canonical SMILES
O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1
    Show/Hide
InChI
InChI=1S/C17H13ClF3NO2/c18-13-7-12(17(19,20)21)4-5-15(13)24-9-10-2-1-3-11(6-10)14-8-16(23)22-14/h1-7,14H,8-9H2,(H,22,23)
    Show/Hide
InChIKey
XHCXWMHKFLLUMU-UHFFFAOYSA-N
Physicochemical Property
logP
4.4988
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
38.33
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155146102
ChEMBL ID
CHEMBL4874670
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06353, Mas-related G-protein coupled receptor member X4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS