General Information of the Compound
Compound ID
CP0956814
Compound Name
(S)-2-((S)-1-((S)-2-((S)-1-((6S,9S,12S,15S,18S)-15-((1H-imidazol-4-yl)methyl)-1-amino-18-(4-aminobutyl)-6-((S)-1-((2S,5S,8S,11S,14S,17S)-17,21-diamino-5-(3-amino-3-oxopropyl)-14-benzyl-2,11-bis(3-guanidinopropyl)-8-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazahenicosane)pyrrolidine-2-carboxamido)-12-(hydroxymethyl)-1-imino-9-isobutyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosane)pyrrolidine-2-carboxamido)-4-(methylthio)butanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanoic acid
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Formula
C93H149N31O20S
Molecular Weight
2053.479
Canonical SMILES
CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
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InChI
InChI=1S/C93H149N31O20S/c1-53(2)45-65(81(134)121-69(51-125)84(137)119-67(48-57-49-104-52-109-57)83(136)112-59(26-12-14-37-95)77(130)108-50-74(127)122-41-18-30-70(122)85(138)116-64(35-44-145-4)89(142)124-43-20-32-72(124)87(140)120-68(90(143)144)47-56-23-9-6-10-24-56)118-79(132)61(28-16-39-106-92(100)101)114-86(139)71-31-19-42-123(71)88(141)63(29-17-40-107-93(102)103)115-80(133)62(33-34-73(97)126)111-75(128)54(3)110-78(131)60(27-15-38-105-91(98)99)113-82(135)66(46-55-21-7-5-8-22-55)117-76(129)58(96)25-11-13-36-94/h5-10,21-24,49,52-54,58-72,125H,11-20,25-48,50-51,94-96H2,1-4H3,(H2,97,126)(H,104,109)(H,108,130)(H,110,131)(H,111,128)(H,112,136)(H,113,135)(H,114,139)(H,115,133)(H,116,138)(H,117,129)(H,118,132)(H,119,137)(H,120,140)(H,121,134)(H,143,144)(H4,98,99,105)(H4,100,101,106)(H4,102,103,107)/t54-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m0/s1
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InChIKey
IYLKYCXKIPAUBE-PBLIPAAASA-N
Physicochemical Property
logP
-7.11899
Rotatable Bonds
65
Heavy Atom Count
145
Polar Areas
832.29
Hydrogen Bond Donor Count
29
Hydrogen Bond Acceptor Count
27
Complexity
145

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4745212
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05078, Apelin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000066 Chem-5 Rattus norvegicus (Rat)  1
1
EC50 = 74.13 nM
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