General Information of the Compound
Compound ID
CP0956202
Compound Name
2-[3-(N-Methyl-N-phenylethylamino)propyl]-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
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Structure
Formula
C29H33N3
Molecular Weight
423.604
Canonical SMILES
CN(CCCN1CCc2c([nH]c3ccccc23)C1c1ccccc1)CCc1ccccc1
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InChI
InChI=1S/C29H33N3/c1-31(21-17-23-11-4-2-5-12-23)19-10-20-32-22-18-26-25-15-8-9-16-27(25)30-28(26)29(32)24-13-6-3-7-14-24/h2-9,11-16,29-30H,10,17-22H2,1H3
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InChIKey
VTCDQYAWFPIBBB-UHFFFAOYSA-N
Physicochemical Property
logP
5.68
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
22.27
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118724304
ChEMBL ID
CHEMBL3360562
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01509, Sigma non-opioid intracellular receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
Ki = 11 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000004 SH-SY5Y Homo sapiens (Human)  1
1
IC50 = 11800 nM
   TI
   LI
   LO
   TS