General Information of the Compound
Compound ID
CP0950533
Compound Name
5-(4-{3-[1-Biphenyl-4-yl-eth-(E)-ylideneaminooxy]-propoxy}-benzyl)-thiazolidine-2,4-dione
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Structure
Formula
C27H26N2O4S
Molecular Weight
474.582
Canonical SMILES
C/C(=N\OCCCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccc(-c2ccccc2)cc1
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InChI
InChI=1S/C27H26N2O4S/c1-19(21-10-12-23(13-11-21)22-6-3-2-4-7-22)29-33-17-5-16-32-24-14-8-20(9-15-24)18-25-26(30)28-27(31)34-25/h2-4,6-15,25H,5,16-18H2,1H3,(H,28,30,31)/b29-19+
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InChIKey
RTWUMNZQXDWRGR-VUTHCHCSSA-N
Physicochemical Property
logP
5.4574
Rotatable Bonds
10
Heavy Atom Count
34
Polar Areas
76.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44348303
ChEMBL ID
CHEMBL124790
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS