General Information of the Compound
Compound ID
CP0947856
Compound Name
(R)-N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-3-methyl-1-oxobutan-2-yl)-3-(trifluoromethyl)benzamide
    Show/Hide
Structure
Formula
C28H29F3N6O4
Molecular Weight
570.572
Canonical SMILES
CC(C)[C@@H](NC(=O)c1cccc(C(F)(F)F)c1)C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1ccc2[nH]ncc2c1
    Show/Hide
InChI
InChI=1S/C28H29F3N6O4/c1-16(2)22(33-23(38)17-5-4-6-19(13-17)28(29,30)31)24(39)36-11-9-27(10-12-36)25(40)35(3)26(41)37(27)20-7-8-21-18(14-20)15-32-34-21/h4-8,13-16,22H,9-12H2,1-3H3,(H,32,34)(H,33,38)/t22-/m1/s1
    Show/Hide
InChIKey
TXQTVHLHNXMKAX-JOCHJYFZSA-N
Physicochemical Property
logP
3.7959
Rotatable Bonds
5
Heavy Atom Count
41
Polar Areas
118.71
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118417600
ChEMBL ID
CHEMBL4647181
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01786, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000742 FreeStyle 293-F Homo sapiens (Human)  1
1
IC50 = 340 nM
   TI
   LI
   LO
   TS