General Information of the Compound
Compound ID
CP0946224
Compound Name
(S)-2-(2-((S)-2-((S)-1-((6S,9S,12S,15S,18S)-15-((1H-imidazol-4-yl)methyl)-1-amino-6-((S)-1-((2S,5S,8S,11S,14S,17S,45S)-45-amino-5-(3-amino-3-oxopropyl)-17-(4-aminobutyl)-46-(4-benzoylphenyl)-14-benzyl-2,8,11-tris(3-guanidinopropyl)-4,7,10,13,16,19,44-heptaoxo-22,25,28,31,34,37,40-heptaoxa-3,6,9,12,15,18,43-heptaazahexatetracontane)pyrrolidine-2-carboxamido)-18-(4-aminobutyl)-12-(hydroxymethyl)-1-imino-9-isobutyl-8-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosane)pyrrolidine-2-carboxamido)hexanamido)-2-methylpropanamido)-3-(4-bromophenyl)propanoic acid
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Formula
C130H205BrN36O30
Molecular Weight
2832.196
Canonical SMILES
CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCNC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)O
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InChI
InChI=1S/C130H205BrN36O30/c1-7-8-29-94(118(182)164-130(4,5)125(190)163-100(124(188)189)75-84-40-44-87(131)45-41-84)157-119(183)102-36-23-56-166(102)107(171)78-150-110(174)90(30-15-17-49-132)153-116(180)99(76-88-77-144-80-151-88)161-117(181)101(79-168)162-121(185)104(72-81(2)3)165(6)122(186)96(34-21-53-148-128(140)141)159-120(184)103-37-24-57-167(103)123(187)97(35-22-54-149-129(142)143)158-114(178)95(46-47-105(135)169)156-113(177)92(32-19-51-146-126(136)137)154-112(176)93(33-20-52-147-127(138)139)155-115(179)98(74-82-25-11-9-12-26-82)160-111(175)91(31-16-18-50-133)152-106(170)48-58-191-60-62-193-64-66-195-68-70-197-71-69-196-67-65-194-63-61-192-59-55-145-109(173)89(134)73-83-38-42-86(43-39-83)108(172)85-27-13-10-14-28-85/h9-14,25-28,38-45,77,80-81,89-104,168H,7-8,15-24,29-37,46-76,78-79,132-134H2,1-6H3,(H2,135,169)(H,144,151)(H,145,173)(H,150,174)(H,152,170)(H,153,180)(H,154,176)(H,155,179)(H,156,177)(H,157,183)(H,158,178)(H,159,184)(H,160,175)(H,161,181)(H,162,185)(H,163,190)(H,164,182)(H,188,189)(H4,136,137,146)(H4,138,139,147)(H4,140,141,148)(H4,142,143,149)/t89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-/m0/s1
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InChIKey
FGRUWACXISNBRQ-HFRJFDJDSA-N
Physicochemical Property
logP
-4.84902
Rotatable Bonds
100
Heavy Atom Count
197
Polar Areas
1034.07
Hydrogen Bond Donor Count
34
Hydrogen Bond Acceptor Count
37
Complexity
197

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4759447
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05078, Apelin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000066 Chem-5 Rattus norvegicus (Rat)  1
1
EC50 = 89.13 nM
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