General Information of the Compound
Compound ID
CP0928401
Compound Name
(R)-N-(1-(1-(1H-Indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-3-methyl-1-oxobutan-2-yl)-2-methyl-5-(trifluoromethyl)benzamide
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Structure
Formula
C29H31F3N6O4
Molecular Weight
584.599
Canonical SMILES
Cc1ccc(C(F)(F)F)cc1C(=O)N[C@@H](C(=O)N1CCC2(CC1)C(=O)N(C)C(=O)N2c1ccc2[nH]ncc2c1)C(C)C
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InChI
InChI=1S/C29H31F3N6O4/c1-16(2)23(34-24(39)21-14-19(29(30,31)32)6-5-17(21)3)25(40)37-11-9-28(10-12-37)26(41)36(4)27(42)38(28)20-7-8-22-18(13-20)15-33-35-22/h5-8,13-16,23H,9-12H2,1-4H3,(H,33,35)(H,34,39)/t23-/m1/s1
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InChIKey
DJIQHFHIIHEAKJ-HSZRJFAPSA-N
Physicochemical Property
logP
4.10432
Rotatable Bonds
5
Heavy Atom Count
42
Polar Areas
118.71
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118417808
ChEMBL ID
CHEMBL4634958
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01786, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000742 FreeStyle 293-F Homo sapiens (Human)  1
1
IC50 = 4900 nM
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