General Information of the Compound
Compound ID
CP0921973
Compound Name
(S)-N-(2,6-dichloro-4-(dimethylcarbamoyl)phenyl)-1,3-dioxo-2-((1S,2R)-2-phenylcyclopropyl)hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide
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Structure
Formula
C25H25Cl2N5O4
Molecular Weight
530.412
Canonical SMILES
CN(C)C(=O)c1cc(Cl)c(NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)[C@@H]3C2)c(Cl)c1
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InChI
InChI=1S/C25H25Cl2N5O4/c1-29(2)22(33)15-10-17(26)21(18(27)11-15)28-24(35)30-8-9-31-20(13-30)23(34)32(25(31)36)19-12-16(19)14-6-4-3-5-7-14/h3-7,10-11,16,19-20H,8-9,12-13H2,1-2H3,(H,28,35)/t16-,19+,20+/m1/s1
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InChIKey
QZCVQRVVICEEFU-UXPWSPDFSA-N
Physicochemical Property
logP
3.7316
Rotatable Bonds
4
Heavy Atom Count
36
Polar Areas
93.27
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56666261
ChEMBL ID
CHEMBL1813103
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 77 nM
   TI
   LI
   LO
   TS
2
IC50 = 120 nM
   TI
   LI
   LO
   TS
CL000426 Shh Light II Mus musculus (Mouse)  1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS