General Information of the Compound
Compound ID
CP0903358
Compound Name
N-(2,6-difluorobenzyl)-4-(2-fluorobenzoyl)-1H-pyrrole-2-carboxamide
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Structure
Formula
C19H13F3N2O2
Molecular Weight
358.319
Canonical SMILES
O=C(NCc1c(F)cccc1F)c1cc(C(=O)c2ccccc2F)c[nH]1
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InChI
InChI=1S/C19H13F3N2O2/c20-14-5-2-1-4-12(14)18(25)11-8-17(23-9-11)19(26)24-10-13-15(21)6-3-7-16(13)22/h1-9,23H,10H2,(H,24,26)
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InChIKey
XRNPOWBGKGBXDS-UHFFFAOYSA-N
Physicochemical Property
logP
3.593
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
61.96
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49798296
ChEMBL ID
CHEMBL1171612
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00861, Mitogen-activated protein kinase 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000293 HLF Homo sapiens (Human)  1
1
IC50 = 1584.89 nM
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