General Information of the Compound
Compound ID
CP0902675
Compound Name
2-(5-methylbenzo[b]thiophen-3-yl)-1-((2R,3R)-3-phenyl-2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanone
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Structure
Formula
C27H32N2OS
Molecular Weight
432.633
Canonical SMILES
Cc1ccc2scc(CC(=O)N3CCC[C@H](c4ccccc4)[C@@H]3CN3CCCC3)c2c1
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InChI
InChI=1S/C27H32N2OS/c1-20-11-12-26-24(16-20)22(19-31-26)17-27(30)29-15-7-10-23(21-8-3-2-4-9-21)25(29)18-28-13-5-6-14-28/h2-4,8-9,11-12,16,19,23,25H,5-7,10,13-15,17-18H2,1H3/t23-,25+/m1/s1
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InChIKey
LTGGFYHDQGKFSS-NOZRDPDXSA-N
Physicochemical Property
logP
5.62282
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44448469
ChEMBL ID
CHEMBL255927
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 15.85 nM
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   LI
   LO
   TS