General Information of the Compound
Compound ID
CP0895579
Compound Name
1-(2-(benzyloxy)-5-chlorobenzyl)-N-(4-(hydroxymethyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide hydrochloride
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Structure
Formula
C26H25Cl2N3O3
Molecular Weight
498.41
Canonical SMILES
Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1.Cl
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InChI
InChI=1S/C26H24ClN3O3.ClH/c1-18-13-24(26(32)28-23-10-7-19(16-31)8-11-23)29-30(18)15-21-14-22(27)9-12-25(21)33-17-20-5-3-2-4-6-20;/h2-14,31H,15-17H2,1H3,(H,28,32);1H
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InChIKey
RNXOLWASFROMKB-UHFFFAOYSA-N
Physicochemical Property
logP
5.63862
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
76.38
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44568182
ChEMBL ID
CHEMBL520438
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01205, Prostaglandin E2 receptor EP1 subtype
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 6.31 nM
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   LI
   LO
   TS
2
Ki = 39.81 nM
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   LI
   LO
   TS